Bioscience & Medical

Image of bioscience banner

The Bioscience & Medical technology area contains solutions ranging from the medical device, diagnostic, and therapeutic fields to next generation drop-in biofuels, biodefense sensors and detectors, and computational biochemical imaging and software.  

The portfolio includes technologies related to:

Search in Bioscience & Medical
Advanced Options
Featured Opportunities
Miniaturized Chemical Detectors for Point-of-Care Diagnosis

Sandia’s mini-PDID makes it possible to diagnose illnesses by identifying...
One-Pot Bioconversion of Distiller's Grains to Advanced Biofuels

Increases in bioethanol production throughout the US has led to...
RetSynth Software

RetSynth is a comprehensive tool for rapidly identifying all optimal...
Quenching of Unincorporated Amplification Signal Reporters (QUASR)

Sandia’s QUASR modification to LAMP helps satisfy the requirements for...
Featured Opportunity (31)
Patents & Applications (244)
Patent Title Patent Number Grant Date
Enhanced Electronic Sensors Pending Pending
SMALL MOLECULE INHIBITORS FOR TREATMENT OF ALPHA VIRUSES 11,564,919 01/31/2023
METHODS OF PRODUCING LIPID-DERIVED COMPOUNDS AND HOST CELLS THEREOF 11,560,576 01/24/2023
MICROFLUIDIC PACKAGE AND METHOD OF MAKING THE SAME 11,554,369 01/17/2023
OPTICALLY PUMPED GRADIENT MAGNETOMETER 11,543,474 01/03/2023
Engineering RuBisCo for Food Safety 11,518,989 12/06/2022
Alkyl Dialkoxyalkanoates as Bioderived, High Cetane Diesel Fuels 11,492,565 11/08/2022
ENDPOINT DETECTION OF AMPLIFIED NUCLEIC ACIDS 11,473,141 10/18/2022
ENGINEERED HOSTS WITH EXOGENOUS LIGNINASE AND USES THEREOF 11,453,895 09/27/2022
LIPID COMPOSITION FOR THE DELIVERY OF THERAPEUTIC CARGOS 11,433,121 09/06/2022
SOLID-STATE TUNING BEHAVIOR IN ACOUSTIC RESONATORS 11,405,014 08/02/2022
Detection of Bioagents Using a Shear Horizontal Surface Acoustic Wave Biosensor 11,378,576 07/05/2022
REAL TIME AUTONOMOUS SURVEILLANCE OF PATHOGENS 11,366,116 06/21/2022
Enrichment of amino acids from biomass residuum 11,326,193 05/10/2022
BIOCHEMICAL UPGRADING OF HIGH-PROTEIN BIOMASS AND GRAIN PRODUCTS 11,312,978 04/26/2022
Switch assembly with integrated tuning capability 11,296,420 04/05/2022
VOLATILE ORGANIC COMPOUND DETECTION DEVICE 11,272,875 03/15/2022
COMPOUNDS THAT INDUCE OCTANE OVERBOOSTING 11,225,622 01/18/2022
FUNCTIONALIZED COATING POLYMERS AND USES THEREOF 11,203,702 12/21/2021
Fatty Acid Derived Alkyl Ether Fuels for Compression Ignition 11,193,075 12/07/2021
ALGAL HARVESTING AND WATER FILTRATION 11,186,507 11/30/2021
Check valves for microfluidic systems and methods thereof 11,130,129 09/28/2021
Promoters and uses thereof 11,098,306 08/24/2021
Therapeutic phages and methods thereof 11,066,691 07/20/2021
Microneedle-based electrical impedance sensor to monitor plant water status in real time 11,060,989 07/13/2021
Lipid-coated particles for treating viral infections 11,045,554 06/29/2021
Seizure detection device 11,020,042 06/01/2021
Tunable metal-organic framework compositions and methods thereof 11,007,516 05/18/2021
Neural interface methods and apparatus to provide artificial sensory capabilities to a subject 10,993,665 05/04/2021
MODULAR ASSEMBLIES AND SYSTEMS FOR CELL CULTURES AND METHODS THEREOF 10,988,723 04/27/2021
Protein and nucleic acid detection for microfluidic devices 10,981,174 04/20/2021
DETECTION OF METABOLITES FOR CONTROLLED SUBSTANCES 10,969,398 04/06/2021
Shape-preserving polymeric replication of biological matter 10,947,349 03/16/2021
Terpene Synthases for Biofuel Production and Methods Thereof 10,947,563 03/16/2021
EXPANDED PORE PARTICLES AND DELIVERY METHODS THEREOF 10,933,027 03/02/2021
Octane hyperboosting in fuel blends 10,899,988 01/26/2021
Conversion of lignin into a water-soluble polyacid using a MOF catalyst 10,800,891 10/13/2020
Detection of active and latent infections with microfluidic devices and systems thereof 10,786,811 09/29/2020
Magnetically-recoverable catalysts for depolymerization 10,767,027 09/08/2020
APPARATUS, METHOD AND SYSTEM FOR IMAGING AND UTILIZATION OF SEM CHARGED PARTICLES 10,770,262 09/08/2020
Selective oxidation of 5-methylcytosine by TET-family proteins 10,731,204 08/04/2020
Microfluidic platform for multiplexed detection in single cells and methods thereof 10,731,205 08/04/2020
Endpoint detection of amplified nucleic acids 10,724,091 07/28/2020
Microfluidic package and method of making the same 10,717,079 07/21/2020
Miniaturized pulsed discharge ionization detector, non-radioactive ionization sources, and methods thereof 10,697,934 06/30/2020
Methods for treating diseases related to the wnt pathway 10,624,949 04/21/2020
Fluid delivery manifolds and microfluidic systems 10,627,366 04/21/2020
Method and apparatus for purifying nucleic acids and performing polymerase chain reaction assays using an immiscible fluid 10,590,477 03/17/2020
Shape-preserving polymeric replication of biological matter 10,538,632 01/21/2020
Check valves for microfluidic systems and methods thereof 10,478,818 11/19/2019
Non-contact temperature control system for microfluidic devices 10,406,528 09/10/2019
Terpene synthases for biofuel production and methods thereof 10,400,254 09/03/2019
DEVICES, SYSTEMS, AND METHODS FOR DETECTING NUCLEIC ACIDS USING SEDIMENTATION 10,384,202 08/20/2019
Nonaqueous redox flow battery electrolyte comprising an ionic liquid with a metal cation coordinated to redox-active ligands 10,305,133 05/28/2019
Linear peptides that mimic structural epitopes for antibody assays 10,267,788 04/23/2019
Shear horizontal surface acoustic wave (SH-SAW) resonators and arrays thereof 10,261,078 04/16/2019
Detection of metabolites for controlled substances 10,254,298 04/09/2019
Miniaturized pulsed discharge ionization detector, non-radioactive ionization sources, and methods thereof 10,197,532 02/05/2019
Trajectory-based triggering system for hyperspectral imaging flow cytometer 10,180,398 01/15/2019
Microsampler and method of making the same 10,161,835 12/25/2018
Sealed micro gas chromatography columns and methods thereof 10,151,732 12/11/2018
Microneedle arrays for biosensing and drug delivery 10,136,846 11/27/2018
Biomimetic membranes and methods of making biomimetic membranes 10,130,916 11/20/2018
AMPLIFICATION OF BIOLOGICAL TARGETS VIA ON-CHIP CULTURE FOR BIOSENSING 10,126,299 11/13/2018
Tandem biochemical and thermochemical conversion of algal biomass 10,077,454 09/18/2018
Detection of bioagents using a shear horizontal surface acoustic wave biosensor 10,031,135 07/24/2018
Systems, devices, and methods for agglutination assays using sedimentation 10,024,849 07/17/2018
Porous nanoparticle-supported lipid bilayers (protocells) for targeted delivery and methods of using same 10,022,327 07/17/2018
Systems, devices, and methods for agglutination assays using sedimentation 10,024,849 07/17/2018
Atomic magnetometer with multiple spatial channels 9,995,800 06/12/2018
High-temperature, adhesive-based microvalves and uses thereof 9,995,411 06/12/2018
Diagnostic/drug delivery "sense-respond" devices, systems, and uses thereof 9,987,427 06/05/2018
DNA/RNA sequencing using a semiconducting nanopore 9,988,677 06/05/2018
DNA/RNA sequencing using a semiconducting nanopore 9,988,677 06/05/2018
Methods of expanding bacteriophage host-range and bacteriophage produced by the methods 9,988,608 06/05/2018
Microfluidic platform for multiplexed detection in single cells and methods thereof 9,957,554 05/01/2018
Biological detector and method 9,958,516 05/01/2018
Innovative nanopore sequencing technology including a self-assembled porous membrane 9,927,397 03/27/2018
Optoelectronic system and apparatus for connection to biological systems 9,907,496 03/06/2018
Quantitative detection of pathogens in centrifugal microfluidic disks 9,903,001 02/27/2018
Amplification of biological targets via on-chip culture for biosensing 9,857,370 01/02/2018
Toroidal mesoporous silica nanoparticles (TMSNPs) and related protocells 9,855,217 01/02/2018
Method and apparatus for purifying nucleic acids and performing polymerase chain reaction assays using an immiscible fluid 9,803,238 10/31/2017
Devices, systems, and methods for detecting nucleic acids using sedimentation 9,795,961 10/24/2017
System and method for detecting components of a mixture including a valving scheme for competition assays 9,766,230 09/19/2017
Massively parallel diffuse optical tomography 9,750,413 09/05/2017
Microneedle arrays for biosensing and drug delivery 9,743,870 08/29/2017
Microneedle arrays for biosensing and drug delivery 9,737,247 08/22/2017
Metal-organic framework catalysts for selective cleavage of aryl-ether bonds 9,718,748 08/01/2017
System and method for detecting components of a mixture including a valving scheme for competition assays 9,702,871 07/11/2017
Catheterized plasma X-ray source 9,681,846 06/20/2017
Metal-organic frameworks for adsorption and separation of noble gases 9,662,632 05/30/2017
Porous nanoparticle-supported lipid bilayers (protocells) for targeted delivery and methods of using same 9,579,283 02/28/2017
Fluid delivery manifolds and microfluidic systems 9,579,649 02/28/2017
Neural interface methods and apparatus to provide artificial sensory capabilities to a subject 9,549,704 01/24/2017
Affinity selection of Nipah and Hendra virus-related vaccine candidates from a complex random peptide library displayed on bacteriophage virus-like particles 9,549,976 01/24/2017
Dye and pigment-free structural colors and angle-insensitive spectrum filters 9,547,107 01/17/2017
Miniature acoustic wave lysis system and uses thereof 9,512,421 12/06/2016
System and method for detecting components of a mixture including tooth elements for alignment 9,500,579 11/22/2016
Biomimetic membranes and methods of making biomimetic membranes 9,486,742 11/08/2016
Protocells and their use for targeted delivery of multicomponent cargos to cancer cells 9,480,653 11/01/2016
Devices, systems, and methods for microscale isoelectric fractionation 9,409,357 08/09/2016
Micropores and methods of making and using thereof 9,404,913 08/02/2016
Apparatus comprising magnetically actuated valves and uses thereof 9,389,231 07/12/2016
Colorometric detection of water using MOF-polymer films and composites 9,347,923 05/24/2016
Multiplexed microfluidic approach for nucleic acid enrichment 9,322,014 04/26/2016
Multiplexed microfluidic approach for nucleic acid enrichment 9,322,014 04/26/2016
Toxin activity assays, devices, methods and systems therefor 9,304,128 04/05/2016
Devices, systems, and methods for conducting assays with improved sensitivity using sedimentation 9,304,129 04/05/2016
Sub-wavelength antenna enhanced bilayer graphene tunable photodetector 9,293,627 03/22/2016
Systems, devices, and methods for agglutination assays using sedimentation 9,244,065 01/26/2016
Microfluidic devices and methods including porous polymer monoliths 9,201,069 12/01/2015
Biological detector and method 9,194,921 11/24/2015
Microfluidic devices, systems, and methods for quantifying particles using centrifugal force 9,186,668 11/17/2015
Multifunctional thin film surface 9,157,161 10/13/2015
Microfluidic device for acoustic cell lysis 9,096,823 08/04/2015
Methods and materials for deconstruction of biomass for biofuels production 9,024,111 05/05/2015
Devices, systems, and methods for microscale isoelectric fractionation 9,005,417 04/14/2015
Multi-analyte analysis of saliva biomarkers as predictors of periodontal and pre-implant disease 9,002,654 04/07/2015
Protocells and their use for targeted delivery of multicomponent cargos to cancer cells 8,992,984 03/31/2015
Devices, systems, and methods for conducting assays with improved sensitivity using sedimentation 8,962,346 02/24/2015
Microchannel gel electrophoretic separation systems and methods for preparing and using 8,961,766 02/24/2015
Devices, systems, and methods for conducting sandwich assays using sedimentation 8,945,914 02/03/2015
Microfluidic hubs, systems, and methods for interface fluidic modules 8,940,147 01/27/2015
Haptic device for telerobotic surgery 8,924,009 12/30/2014
Materials, methods and devices to detect and quantify water vapor concentrations in an atmosphere 8,904,850 12/09/2014
Methods, microfluidic devices, and systems for detection of an active enzymatic agent 8,871,496 10/28/2014
Dynamic tuning of chemiresistor sensitivity using mechanical strain 8,846,406 09/30/2014
Microelectroporation device for genomic screening 8,828,736 09/09/2014
Methods and devices for immobilization of single particles in a virtual channel in a hydrodynamic trap 8,815,177 08/26/2014
Methods for integrating a functional component into a microfluidic device 8,808,588 08/19/2014
Porous nanoparticle supported lipid bilayer nanostructures 8,734,816 05/27/2014
Microfluidic device having an immobilized pH gradient and page gels for protein separation and analysis 8,728,290 05/20/2014
Detection of bioagents using a shear horizontal surface acoustic wave biosensor 8,709,791 04/29/2014
Dielectrokinetic chromatography and devices thereof 8,702,946 04/22/2014
Microfluidic devices and methods including porous polymer monoliths 8,703,058 04/22/2014
Biological detector and method 8,698,494 04/15/2014
Dual-etalon cavity ring-down frequency-comb spectroscopy with broad band light source 8,693,004 04/08/2014
Hyperspectral stimulated emission depletion microscopy and methods of use thereof 8,686,363 04/01/2014
Optically transduced MEMS magnetometer 8,674,689 03/18/2014
High-Frequency Shear-Horizontal Surface Acoustic Wave Sensor 8,669,688 03/11/2014
Functionalized lignin, rubber containing functionalized lignin and products containing such rubber composition 8,664,305 03/04/2014
Micropores and methods of making and using thereof 8,585,916 11/19/2013
Identification of novel subgroups of high-risk pediatric precursor B acute lymphoblastic leukemia, outcome correlations and diagnostic and therapeutic methods related to same 8,568,974 10/29/2013
Coaxial microreactor for particle synthesis 8,563,325 10/22/2013
Stress-tuned conductor-polymer composite for use in sensors 8,562,878 10/22/2013
Microchannel gel electrophoretic separation systems and methods for preparing and using 8,524,060 09/03/2013
Multidimensional bioseparation with modular microfluidics 8,518,346 08/27/2013
Apparatus and method for measuring single cell and sub-cellular photosynthetic efficiency 8,481,974 07/09/2013
Method of detecting cancer in a single cell using mitochondrial correlation microscopy 8,472,752 06/25/2013
Materials and methods for stabilizing nanoparticles in salt solutions 8,461,300 06/11/2013
High-frequency shear-horizontal surface acoustic wave sensor 8,436,509 05/07/2013
High temperature flow-through device for rapid solubilization and analysis 8,426,135 04/23/2013
System for particle concentration and detection 8,398,839 03/19/2013
Method for forming polymerized microfluidic devices 8,394,312 03/12/2013
Biological detector and method 8,384,381 02/26/2013
Biological detector and method 8,339,135 12/25/2012
Microfluidic device having an immobilized pH gradient and PAGE gels for protein separation and analysis 8,329,016 12/11/2012
Micromachined patch-clamp apparatus 8,323,955 12/04/2012
Portable dual field gradient force multichannel flow cytometer device with a dual wavelength low noise detection scheme 8,293,089 10/23/2012
Dielectrophoresis device and method having nonuniform arrays for manipulating particles 8,257,571 09/04/2012
Method for concentration and separation of biological organisms by ultrafiltration and dielectrophoresis 8,257,568 09/04/2012
Methods and Systems for Integrating Fluid Dispensing Technology with Stereolithography 8,252,223 08/28/2012
Aerosol method for nano silver-silica composite anti-microbial agent 8,246,933 08/21/2012
Atomic magnetometer 8,212,556 07/03/2012
Micromanifold assembly 8,163,254 04/24/2012
Particle sorter comprising a fluid displacer in a closed-loop fluid circuit 8,162,149 04/24/2012
Method for voltage-gated protein fractionation 8,163,154 04/24/2012
Method for detecting cancer in a single cell using mitochondrial correlation microscopy 8,131,112 03/06/2012
Method and apparatus for detecting an analyte 8,065,904 11/29/2011
Method for forming polymerized microfluidic devices 8,047,829 11/01/2011
Information-based self-organization of sensor nodes of a sensor network 8,022,987 09/20/2011
Electrode array for neural stimulation 8,000,804 08/16/2011
Microfluidic devices and methods for integrated flow cytometry 7,999,937 08/16/2011
Active micromixer using surface acoustic wave streaming 7,942,568 05/17/2011
Simultaneous sample manipulation and sensing using surface acoustic waves 7,878,063 02/01/2011
System and method for statistically monitoring and analyzing sensed conditions 7,877,234 01/25/2011
System and method for statistically monitoring and analyzing sensed conditions 7,865,336 01/04/2011
Preconcentration and separation of analytes in microchannels 7,828,948 11/09/2010
Concentration and separation of biological organisms by ultrafiltration and dielectrophoresis 7,811,439 10/12/2010
Tortuous path chemical preconcentrator 7,799,280 09/21/2010
Vesicle-based method for collecting, manipulating, and chemically processing trace macromolecular species 7,776,357 08/17/2010
System and method for statistically monitoring and analyzing sensed conditions 7,756,682 07/13/2010
Dialysis membrane for separation on microchips 7,754,077 07/13/2010
Microfluidic device for the assembly and transport of microparticles 7,744,737 06/29/2010
Methods for improved preconcentrators 7,727,314 06/01/2010
Dielectrophoretic columnar focusing device 7,713,395 05/11/2010
Modular high voltage power supply for chemical analysis 7,710,086 05/04/2010
Method of photocatalytic nanotagging 7,704,489 04/27/2010
Insulator-based DEP with impedance measurements for analyte detection 7,678,256 03/16/2010
Methods and devices for high-throughput dielectrophoretic concentration 7,666,289 02/23/2010
Method for a microfluidic weaklink device 7,625,474 12/01/2009
Polymeric salt bridges for conducting electric current in microfluidic devices 7,618,524 11/17/2009
Methods and devices for protein assays 7,611,834 11/03/2009
Surface engineered nanoparticles for improved surface enhanced Raman scattering applications and method for preparing same 7,608,461 10/27/2009
High temperature flow-through device for rapid solubilization and analysis 7,592,139 09/22/2009
Complex admixtures of clathrate hydrates in a water desalination method 7,560,028 07/14/2009
Method for converting sucrose to .beta.-D-glucose 7,556,945 07/07/2009
Micromanifold assembly 7,553,455 06/30/2009
Method for dialysis on microchips using thin porous polymer membrane 7,534,315 05/19/2009
Apparatus and method for concentrating and filtering particles suspended in a fluid 7,534,334 05/19/2009
Protein detection system 7,527,977 05/05/2009
Microfluidic microarray systems and methods thereof 7,524,672 04/28/2009
Castable three-dimensional stationary phase for electric field-driven applications 7,488,407 02/10/2009
Portable apparatus for separating sample and detecting target analytes 7,452,507 11/18/2008
Biological preconcentrator 7,422,724 09/09/2008
Dielectrophoresis device and method having non-uniform arrays for manipulating particles 7,419,574 09/02/2008
Method for detecting biomolecules 7,410,762 08/12/2008
Modular high voltage power supply for chemical analysis 7,400,119 07/15/2008
High-pressure microhydraulic actuator 7,384,526 06/10/2008
Apparatus for producing a thin sample band in a microchannel system 7,371,310 05/13/2008
Structural determination of intact proteins using mass spectrometry 7,368,290 05/06/2008
Microfluidic structures and methods for integrating a functional component into a microfluidic device 7,351,380 04/01/2008
Dielectrophoresis device and method having insulating ridges for manipulating particles 7,347,923 03/25/2008
Planar micromixer 7,344,681 03/18/2008
Stationary phase deposition based on onium salts 7,314,505 01/01/2008
Capillary interconnect device 7,311,882 12/25/2007
Method for siting detectors within a facility 7,308,374 12/11/2007
Electrokinetic pump 7,297,246 11/20/2007
Non-planar microfabricated gas chromatography column 7,273,517 09/25/2007
Enzymatic cascade bioreactor 7,264,962 09/04/2007
Carbon monoxide sensor and method of use thereof 7,264,778 09/04/2007
Dialysis on microchips using thin porous polymer membranes 7,264,723 09/04/2007
Reactive ion etched substrates and methods of making and using 7,253,008 08/07/2007
Composition pulse time-of-flight mass flow sensor 7,225,683 06/05/2007
Sample preparation system for microfluidic applications 7,213,473 05/08/2007
High pressure capillary micro-fluidic valve device and a method of fabricating same 7,204,264 04/17/2007
Edge compression manifold apparatus 7,182,371 02/27/2007
Modular high voltage power supply for chemical analysis 7,161,334 01/09/2007
Non-planar chemical preconcentrator 7,118,712 10/10/2006
Electrodes for microfluidic applications 7,094,326 08/22/2006
Method for producing high dielectric strength microvalves 7,022,381 04/04/2006
Single particle electrochemical sensors and methods of utilization 7,022,287 04/04/2006
Dielectrophoretic systems without embedded electrodes 7,014,747 03/21/2006
Piecewise uniform conduction-like flow channels and method therefor 7,005,301 02/28/2006
Modular optical detector system 6,998,598 02/14/2006
Method and apparatus for controlling cross contamination of microfluid channels 6,994,826 02/07/2006
Mobile monolithic polymer elements for flow control in microfluidic devices 6,988,402 01/24/2006
Fluid injection microvalve 6,966,336 11/22/2005
Self-assembled lipid bilayer materials 6,962,747 11/08/2005
Electrokinetically pumped high pressure sprays 6,960,285 11/01/2005
Mobile monolithic polymer elements for flow control in microfluidic devices 6,952,962 10/11/2005
High pressure capillary connector 6,926,313 08/09/2005
Microvalve 6,918,573 07/19/2005
Show More