CRISPR-Cas based system for targeting single-stranded sequences
| Patent Number: | 11661599 |
| Issued: | 5/30/2023 |
| Official Filing: | View the Complete Patent |
| Abstract: | The present invention relates to a CRISPR-Cas based system for targeting nucleic acid sequences. In part, the invention relates to synthetic guiding components for targeting single-stranded sequences, as well as design principles for constructing such components. Also described herein are methods of employing such components, e.g., to repress or activate a desired target within the subject. |
| Filed: | 12/13/2018 |
| Government Interests: | STATEMENT OF GOVERNMENT INTEREST This invention was made with Government support under Contract No. DE-NA0003525 awarded by the United States Department of Energy/National Nuclear Security Administration. The Government has certain rights in the invention. |