Linear peptides that mimic structural epitopes for antibody assays

Patent Number: 10,267,788
Issued: 4/23/2019
Official Filing: View the Complete Patent
Abstract: A method including identifying one or more structures in adjacent sequences of one or more proteins that can be mimicked by a peptide; and assembling a peptide that mimics the one or more secondary structures. A method including assembling epitopes of linked pairs of discontiguous peptide subsequences that mimic one or more structures in sequences of a protein; and assaying antibodies against the epitopes.
Filed: 1/20/2014
Application Number: 14/159,308
Government Interests: STATEMENT OF GOVERNMENT INTEREST This invention was made with Government support under Contract No. DE-NA0003525 awarded by the United States Department of Energy/National Nuclear Security Administration. The Government has certain rights in the invention.