Targeted Antibody Therapeutics

Highly potent SARS-CoV-2 antibodies show pre-clinical efficacy and delayed disease progression

The COVID-19 pandemic has emphasized the need for the global community to rapidly acquire a diverse arsenal of prevention and therapeutic options to address SARS-CoV-2. A flexible and robust solution is needed to impact the current threat and shorten the lead time for discovery of therapeutics for future outbreaks. To address this critical need and support our nation’s commitment to the health of the global community, Sandia National Laboratories has developed an antibody discovery platform for mitigating current and future biological threats.

Researchers at Sandia have identified and engineered highly potent SARS-CoV-2 antibodies with prophylactic and therapeutic efficacy against SARS-CoV-2 in a rodent model of severe infection and disease. These antibodies were identified using Sandia’s proprietary humanized single-domain antibody library and are ideal for the treatment and prevention of mild to moderate COVID-19 disease. Development of second-generation antibodies with efficacy against emerging variants is underway with therapeutic properties comparable to currently deployed therapeutics. These antibody therapies can be used as the foundation for a commercial partner to move forward through their pipeline.