Patent • #US11056332B1. A radio-frequency (RF) surface ion trap chip includes an RF electrode and an integrated capacitive voltage divider in which an intermediate voltage node is capacitively connected between the RF electrode and a ground. A sensor output trace is connected to the intermediate voltage node.
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Microfabricated linear Paul-Straubel ion trap
Patent • #US7928375B1. An array of microfabricated linear Paul-Straubel ion traps can be used for mass spectrometric applications. Each ion trap comprises two parallel inner RF electrodes and two parallel outer DC control electrodes symmetric about a central trap axis and suspended over an opening in a substrate. Neighboring ion traps in...
Microfabricated particle focusing device
Patent • #US8425749B1. A microfabricated particle focusing device comprises an acoustic portion to preconcentrate particles over large spatial dimensions into particle streams and a dielectrophoretic portion for finer particle focusing into single-file columns. The device can be used for high throughput assays for which it is necessary to isolate and investigate small...
Microfabricated triggered vacuum switch
Patent • #US7714240B1. A microfabricated vacuum switch is disclosed which includes a substrate upon which an anode, cathode and trigger electrode are located. A cover is sealed over the substrate under vacuum to complete the vacuum switch. In some embodiments of the present invention, a metal cover can be used in place...
Microfluidic device for acoustic cell lysis
Patent • #US9096823B1. A microfluidic acoustic-based cell lysing device that can be integrated with on-chip nucleic acid extraction. Using a bulk acoustic wave (BAW) transducer array, acoustic waves can be coupled into microfluidic cartridges resulting in the lysis of cells contained therein by localized acoustic pressure. Cellular materials can then be extracted...
Microfluidic device for the assembly and transport of microparticles
Patent • #US7744737B1. A microfluidic device comprising independently addressable arrays of interdigitated electrodes can be used to assembly and transport large-scale microparticle structures. The device and method uses collective phenomena in a negatively polarized suspension exposed to a high-gradient strong ac electric field to assemble the particles into predetermined locations and then...
Microfluidic device having an immobilized pH gradient and page gels for protein separation and analysis
Patent • #US8728290B1. Disclosed is a novel microfluidic device enabling on-chip implementation of a two-dimensional separation methodology. Previously disclosed microscale immobilized pH gradients (IPG) are combined with perpendicular polyacrylamide gel electrophoresis (PAGE) microchannels to achieve orthogonal separations of biological samples. Device modifications enable inclusion of sodium dodecyl sulfate (SDS) in the second...
Microfluidic device having an immobilized pH gradient and PAGE gels for protein separation and analysis
Patent • #US8329016B1. Disclosed is a novel microfluidic device enabling on-chip implementation of a two-dimensional separation methodology. Previously disclosed microscale immobilized pH gradients (IPG) are combined with perpendicular polyacrylamide gel electrophoresis (PAGE) microchannels to achieve orthogonal separations of biological samples. Device modifications enable inclusion of sodium dodecyl sulfate (SDS) in the second...
Microfluidic hubs, systems, and methods for interface fluidic modules
Patent • #US8940147B1. Embodiments of microfluidic hubs and systems are described that may be used to connect fluidic modules. A space between surfaces may be set by fixtures described herein. In some examples a fixture may set substrate-to-substrate spacing based on a distance between registration surfaces on which the respective substrates rest....
Microfluidic microarray systems and methods thereof
Patent • #US7524672B2. Disclosed are systems that include a manifold in fluid communication with a microfluidic chip having a microarray, an illuminator, and a detector in optical communication with the microarray. Methods for using these systems for biological detection are also disclosed.
Microfluidic package and method of making the same
Patent • #US10717079B2. The present invention relates to encapsulated microfluidic packages and methods thereof. In particular embodiments, the package includes a device, a cradle configured to support the device, and a lid having a bonding surface configured to provide a fluidic seal between itself and the device and/or cradle. Other package configurations,...
Microfluidic package and method of making the same
Patent • #US11554369B2. The present invention relates to encapsulated microfluidic packages and methods thereof. In particular embodiments, the package includes a device, a cradle configured to support the device, and a lid having a bonding surface configured to provide a fluidic seal between itself and the device and/or cradle. Other package configurations,...
Microfluidic platform for multiplexed detection in single cells and methods thereof
Patent • #US10731205B2. The present invention relates to a microfluidic device and platform configured to conduct multiplexed analysis within the device. In particular, the device allows multiple targets to be detected on a single-cell level. Also provided are methods of performing multiplexed analyses to detect one or more target nucleic acids, proteins,...
Microfluidic platform for multiplexed detection in single cells and methods thereof
Patent • #US9957554B1. The present invention relates to a microfluidic device and platform configured to conduct multiplexed analysis within the device. In particular, the device allows multiple targets to be detected on a single-cell level. Also provided are methods of performing multiplexed analyses to detect one or more target nucleic acids, proteins,...
Microfluidic Polymer Valves
Featured Opportunity • In a technological breakthrough, Sandia researchers have developed polymer microvalves to allow fluids to be shuttled as easily in microfluidic chips as they are on a laboratory benchtop. The valves are photopatterned, cast-to-shape microscale polymer elements that can be used to isolate electric fields, and, as a consequence, locally isolate...
Microfluidics
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Microinverters for employment in connection with photovoltaic modules
Patent • #US9143053B1. Microinverters useable in association with photovoltaic modules are described. A three phase-microinverter receives direct current output generated by a microsystems-enabled photovoltaic cell and converts such direct current output into three-phase alternating current out. The three-phase microinverter is interleaved with other three-phase-microinverters, wherein such microinverters are integrated in a photovoltaic...
Micromachined force-balance feedback accelerometer with optical displacement detection
Patent • #US8783106B1. An accelerometer includes a proof mass and a frame that are formed in a handle layer of a silicon-on-an-insulator (SOI). The proof mass is separated from the frame by a back-side trench that defines a boundary of the proof mass. The accelerometer also includes a reflector coupled to a...
Micromachined microwave signal control device and method for making same
Patent • #US7420442B1. A method for fabricating a signal controller, e.g., a filter or a switch, for a coplanar waveguide during the LIGA fabrication process of the waveguide. Both patterns for the waveguide and patterns for the signal controllers are created on a mask. Radiation travels through the mask and reaches a...
Micromagnet PUF readout using a quantum diamond microscope
Patent • #US11796612B1. A physically unclonable function (PUF) and a method of reading it are provided. The PUF is constituted by a microfabricated array of randomly polarized micromagnets disposed on a substrate. The PUF can be read by creating a magnetization map of the PUF from the signal output of a quantum...
Microresonator electrode design
Patent • #US9337800B1. A microresonator with an input electrode and an output electrode patterned thereon is described. The input electrode includes a series of stubs that are configured to isolate acoustic waves, such that the waves are not reflected into the microresonator. Such design results in reduction of spurious modes corresponding to...
Microsampler and method of making the same
Patent • #US10161835B1. An aspect of the present disclosure relates to a microsampler for hermetically sealing a sample. In particular, such microsamplers can be useful for encapsulation of chemical, biological, and explosive samples for the purposes of archival sample storage. Methods of making and using such microsamplers are also described herein.
Microscale autonomous sensor and communications module
Patent • #US8680810B1. Various technologies pertaining to a microscale autonomous sensor and communications module are described herein. Such a module includes a sensor that generates a sensor signal that is indicative of an environmental parameter. An integrated circuit receives the sensor signal and generates an output signal based at least in part...
Microscale Immune and Cell Analysis (MICA)
Featured Opportunity • Researchers at Sandia National Laboratories have created a sophisticated, integrated platform for single-cell manipulation and interrogation. Called Microscale Immune and Cell Analysis (MICA), this platform represents a revolutionary breakthrough in biological research. MICA offers experimenters the ability to understand cell behavior at the molecular and cellular levels with unprecedented speed,...
Microsphere Templated Gallium Nitride Growth and Liftoff
Featured Opportunity • The LED market is one of the fastest growing markets worldwide, driven by demand for clean solid state lighting, LED displays and mobile devices. GaN-based materials are essential components of these technologies. Due to the very high cost and lack of availability of bulk GaN substrates, current GaN production methods...
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