Correlation ion mobility spectroscopy
| DWPI Title: Correlation ion mobility spectrometer (CIMS) for detecting very low levels of analyte has matched filter which correlates ion response signal with ion current modulation to provide correlation mobility spectrum |
| Abstract: Correlation ion mobility spectrometry (CIMS) uses gating modulation and correlation signal processing to improve IMS instrument performance. Closely spaced ion peaks can be resolved by adding discriminating codes to the gate and matched filtering for the received ion current signal, thereby improving sensitivity and resolution of an ion mobility spectrometer. CIMS can be used to improve the signal-to-noise ratio even for transient chemical samples. CIMS is especially advantageous for small geometry IMS drift tubes that can otherwise have poor resolution due to their small size. |
| Use: CIMS for detecting very low levels of analyte. Can also be used to detect narcotics, explosives, and chemical warfare agents. |
| Advantage: Provides CIMS that uses pulse compression techniques to improve signal to noise ratio (SNR) of ion mobility spectrum. Adds more signal energy into a single ion mobility spectroscopy (IMS) measurement cycle to equally improve peak SNR even with more back processing i.e. matched filtering. Effectively averages information content of measurement cycles into one correlation sample interval, thus attaining improved signal fidelity in reduced time interval. Improves resolution and SNR of IMS system by correlating measured ion signal with gating function. Improves performance of CIMS by employing binary or analog modulated gating function. |
| Novelty: The CIMS (10) has a reaction region (22), drift region (25), gating unit (26), preferably an ion shutter e.g. Bradbury-Neilson shutter, Tyndall shutter, gate drive circuit (32), ion collector (27), and matched filter (36). The gate drive circuit applies a gating function, preferably binary or analog modulation, to the gating unit. The ion collector detects ions formed in reaction region (22) and drifting at end of drift region to provide an ion response signal. The matched filter correlates the ion response signal with ion current modulation to provide a correlation mobility spectrum. |
| Filed: 8/15/2005 |
| Application Number: US2005204268A |
| Tech ID: SD 7780.0 |
| This invention was made with Government support under Contract No. DE-NA0003525 awarded by the United States Department of Energy/National Nuclear Security Administration. The Government has certain rights in the invention. |
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