Tunable metal-organic framework compositions and methods thereof

DWPI Title: Metal-organic framework composition useful for treating cell or human, or delivering cargo, comprises metal clusters and ligands coordinating with metal clusters
Abstract: The present invention relates to a metal-organic framework composition, as well as constructs and methods thereof. In one particular example, the composition provides a platform having an emission signal in the deep red to near-infrared (NIR) region.
Use: The MOF composition is useful for treating a cell or a subject (e.g. a human), or delivering a cargo.
Advantage: The MOF composition exhibits minimal toxicity as determined by in vitro or in vivo assays.
Novelty: Metal-organic framework (MOF) composition comprises several metal clusters and ligands coordinating with the metal clusters, where at least one metal cluster comprises a metal ion, at least one ligand is a monodentate ligand, and at least one ligand is a bidentate ligand, where the metal clusters and ligands are characterized by a tetragonal crystal structure, where at least one metal cluster comprises a hexanuclear cluster, where the metal ion is a rare earth metal ion chosen from europium, neodymium, ytterbium, yttrium, terbium, lanthanum, cerium, praseodymium, samarium, gadolinium, dysprosium, holmium, erbium, thulium, and lutetium.
Filed: 5/31/2018
Application Number: US15994904A
Tech ID: SD 14331.1
This invention was made with Government support under Contract No. DE-NA0003525 awarded by the United States Department of Energy/National Nuclear Security Administration. The Government has certain rights in the invention.
Data from Derwent World Patents Index, provided by Clarivate
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