Shape-preserving polymeric replication of biological matter
| DWPI Title: Synthetic construct used to form silica nanolayers on or within biological sample contains polymeric replica of biological sample, oxygen carrier loaded within polymeric replica and optionally endogenous or exogenous oxygen-binding molecule |
| Abstract: The present invention relates to a method of forming silica nanolayers on or within a biological sample, thereby capturing structural details that are present in the sample. The resultant silica composite or silica replica, in turn, can be employed as a template for a replica having those structural details captured in a polymer. Also provided herein are synthetic constructs including a polymeric replica, which can have any useful feature (e.g., oxygen-binding capacity). |
| Use: The construct is useful for forming silica nanolayers on or within a biological sample, to capture structural details that are present in the sample. |
| Advantage: The construct utilizes the polymeric replica with improved oxygen-binding capacity. |
| Novelty: Synthetic construct comprises: a polymeric replica of a biological sample, where the replica comprises a shape-preserved layer comprising a polymeric precursor or a polymer; an oxygen carrier loaded within the polymeric replica; and optionally, at least one endogenous or exogenous oxygen-binding molecule loaded within the polymeric replica. |
| Filed: 12/11/2019 |
| Application Number: US16711150A |
| Tech ID: SD 13866.1 |
| This invention was made with Government support under Contract No. DE-NA0003525 awarded by the United States Department of Energy/National Nuclear Security Administration. The Government has certain rights in the invention. |
| Data from Derwent World Patents Index, provided by Clarivate All rights reserved. Republication or redistribution of Clarivate content, including by framing or similar means, is prohibited without the prior written consent of Clarivate. Clarivate and its logo, as well as all other trademarks used herein are trademarks of their respective owners and used under license. |