|Various embodiments provide materials and methods for synthesizing
protocells for use in targeted delivery of cargo components to cancer
cells. In one embodiment, the lipid bilayer can be fused to the porous
particle core to form a protocell. The lipid bilayer can be modified with
targeting ligands or other ligands to achieve targeted delivery of cargo
components that are loaded within the protocell to a target cell, e.g., a
type of cancer. Shielding materials can be conjugated to the surface of
the lipid bilayer to reduce undesired non-specific binding.