Porous nanoparticle supported lipid bilayer nanostructures

DWPI Title: Protocell nanostructure, useful for delivering cargo component, comprises a porous particle core comprising many pores, and lipid bilayer surrounding the porous particle core to form a protocell
Use: The protocell nanostructure is useful for delivering the cargo component (claimed) to targeted bioactive cells (e.g. cancer cells), where the cargo component is useful in biomedical diagnostics, imaging, disease treatment, drug delivery, and anti-bacteria applications.
Advantage: The lipid bilayer of the protocells provides biocompatibility and improves the protocell colloidal stability. The protocells can readily enter bioactive cells without the support of porous particles. The protocell provides versatile delivery systems. The delivery system using the protocell controls the loading and/or release profile than the delivery systems using liposome only. The delivery system provided by the protocell is simple and has low toxicity than the delivery systems using nanoparticles alone.
Novelty: Protocell nanostructure comprises: a porous particle core (110) comprising many pores; and at least one lipid bilayer (120) surrounding the porous particle core to form a protocell (100), where the protocell is capable of loading one or more cargo components to many pores of the porous particle core and releasing one or more cargo components from the porous particle core across the surrounding lipid bilayer.
Filed: 7/1/2011
Application Number: US13143164A
Tech ID: SD 11566.2
This invention was made with Government support under Contract No. DE-NA0003525 awarded by the United States Department of Energy/National Nuclear Security Administration. The Government has certain rights in the invention.
Data from Derwent World Patents Index, provided by Clarivate
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