Microfluidic package and method of making the same
| DWPI Title: Method of making encapsulated microfluidic package, involves attaching second bonding surface of lid to first bonding surface of device, for forming fluidic seal which results from reaction between first and second reactive groups |
| Abstract: The present invention relates to encapsulated microfluidic packages and methods thereof. In particular embodiments, the package includes a device, a cradle configured to support the device, and a lid having a bonding surface configured to provide a fluidic seal between itself and the device and/or cradle. Other package configurations, as well as methods for making such fluidic seals, are described herein. |
| Use: Method of making encapsulated microfluidic package used for testing test sample such as blood, plasma, serum, transdermal fluid, interstitial fluid, sweat, intraocular fluid, vitreous humor, cerebrospinal fluid, extracellular fluid, lacrimal fluid, tear fluid, sputum, saliva, and mucus. Uses include but are not limited to sample such as microorganism, virus, bacterium, fungus, parasite, helminth, protozoon, cell, tissue, fluid, swab, biological sample, environmental sample, and agricultural sample. |
| Advantage: The fluidic system provides complicated routines to manipulate and analyze small volumes of fluid. The encapsulation method is superior to PDMS based packaging due to the improved seal between the substrate and the lid to form the package. The top surface of the polycarbonate does not undergo further machining in order to maintain a smooth bonding surface. |
| Novelty: The method involves functionalizing a portion of a device (160) to provide a first bonding surface comprising a first reactive group. The device comprises an active area and an inactive area. The active area comprises one or more capture probes. A lid (120) is functionalized to provide a second bonding surface comprising a second reactive group. The lid comprises a recess, an upper surface, and the second bonding surface arranged on a lower surface of the lid. The recess is configured to be fixed above the active area, and the second reactive group is configured to react with the first reactive group. The second bonding surface of the lid is attached to the first bonding surface of the device, for forming a first fluidic seal. The first fluidic seal results from a reaction between the first and second reactive groups and the first fluidic seal is formed in the presence of the one or more capture probes. |
| Filed: 5/27/2020 |
| Application Number: US16884581A |
| Tech ID: SD 13787.3 |
| This invention was made with Government support under Contract No. DE-NA0003525 awarded by the United States Department of Energy/National Nuclear Security Administration. The Government has certain rights in the invention. |
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