Microfluidic devices, systems, and methods for quantifying particles using centrifugal force
| Patent Number: | 9,186,668 |
| Issued: | 11/17/2015 |
| Official Filing: | View the Complete Patent |
| Abstract: | Embodiments of the present invention are directed toward microfluidic systems, apparatus, and methods for measuring a quantity of cells in a fluid. Examples include a differential white blood cell measurement using a centrifugal microfluidic system. A method may include introducing a fluid sample containing a quantity of cells into a microfluidic channel defined in part by a substrate. The quantity of cells may be transported toward a detection region defined in part by the substrate, wherein the detection region contains a density media, and wherein the density media has a density lower than a density of the cells and higher than a density of the fluid sample. The substrate may be spun such that at least a portion of the quantity of cells are transported through the density media. Signals may be detected from label moieties affixed to the cells. |
| Filed: | 9/28/2010 |
| Application Number: | 12/891,956 |
| Related Opportunity: |
ViralFx SpinDx™: Point-of-Care Diagnostics Using Centrifugal Microfluidics |
| Government Interests: | STATEMENT OF GOVERNMENT INTEREST This invention was made with Government support under Contract No. DE-NA0003525 awarded by the United States Department of Energy/National Nuclear Security Administration. The Government has certain rights in the invention. |