Methods for attaching polymerizable ceragenins to water treatment membranes using silane linkages
| DWPI Title: Attaching alkene-functionalized ceragenins to surface of polymer substrate involves treating silane-based coating to surface of substrate and then treating with Type-I compound of acid halides and contacting surface with monomer solution |
| Abstract: This invention relates to methods for chemically grafting and attaching ceragenin molecules to polymer substrates; methods for synthesizing ceragenin-containing copolymers; methods for making ceragenin-modified water treatment membranes and spacers; and methods of treating contaminated water using ceragenin-modified treatment membranes and spacers. Ceragenins are synthetically produced antimicrobial peptide mimics that display broad-spectrum bactericidal activity. Alkene-functionalized ceragenins (e.g., acrylamide-functionalized ceragenins) can be attached to polyamide reverse osmosis membranes using amine-linking, amide-linking, UV-grafting, or silane-coating methods. In addition, silane-functionalized ceragenins can be directly attached to polymer surfaces that have free hydroxyls. |
| Use: The method is useful for attaching polymerizable ceragenins to a surface of a polymer substrate such as polyethylene spacer and polyamide membrane (all calimed)(preferably reverse osmosis membrane) for water treatment and purification and in pharmaceuticals and microchip and electronics industries. |
| Advantage: The method chemically attaches the polymerizable ceragenins to the surface of the polymer substrate thus minimizing and preventing biofouling of water treatment membrane and improving lifetime of the membrane in an economical manner. |
| Novelty: Attaching alkene-functionalized ceragenins to a surface of a polymer substrate comprises: (a) applying a silane-based coating to a surface of a polymer substrate; (b) treating the silane-based coating with a Type-I compound of acid halides with an attached halogen atom i.e. abstracted to leave a stable radical; (c) contacting the Type-I treated surface with a monomer solution of an alkene-functionalized ceragenin monomer, and a solvent; (d) adding a copper-based catalyst and a nitrogen-based ligand; and (e) forming ceragenin-containing copolymer reaction products. |
| Filed: 1/7/2011 |
| Application Number: US2011986221A |
| Tech ID: SD 11236.2 |
| This invention was made with Government support under Contract No. DE-NA0003525 awarded by the United States Department of Energy/National Nuclear Security Administration. The Government has certain rights in the invention. |
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