Method for detecting biomolecules
| DWPI Title: Detecting biomolecules e.g. DNA molecules, involves contacting solution having target biomolecules and indicator molecules with sensor platform having nanoporous film deposited on conducting electrode and measuring current across electrode |
| Abstract: A method for detecting and measuring the concentration of biomolecules in solution, utilizing a conducting electrode in contact with a solution containing target biomolecules, with a film with controllable pore size distribution characteristics applied to at least one surface of the conducting electrode. The film is functionalized with probe molecules that chemically interact with the target biomolecules at the film surface, blocking indicator molecules present in solution from diffusing from the solution to the electrode, thereby changing the electrochemical response of the electrode. |
| Use: For detecting biomolecules i.e. DNA molecules (claimed). |
| Advantage: The method is simple, fast, sensitive, reliable and inexpensive and effectively measuring the presence of fempto-mole target biomolecules. |
| Novelty: Detecting biomolecules (34) involves contacting solution containing target biomolecules and indicator molecules (32) with sensor platform (10) having nanoporous film (22) deposited on a conducting electrode (21) and measuring current across the electrode to detect the presence of biomolecules. |
| Filed: 6/27/2005 |
| Application Number: US2005168247A |
| Tech ID: SD 10002.0 |
| This invention was made with Government support under Contract No. DE-NA0003525 awarded by the United States Department of Energy/National Nuclear Security Administration. The Government has certain rights in the invention. |
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