Brain-targeting single domain antibodies and purification methods
| DWPI Title: New single domain antibody construct comprising first single domain antibody with binding domain, useful for treating or diagnosing disease or malignancy and viral infection, where binding domain comprises first polypeptide comprising first complementarity determining regions |
| Abstract: Provided herein are single domain antibodies (sdAbs) configured for passing the blood brain barrier in a human or mammal brain. Methods of using such sdAbs are also described herein, such as methods of binding to brain cells, binding with and transporting other sdAbs with beneficial functionalities, binding to and transporting biochemical or pharmaceutical species with beneficial functionalities, and treating, diagnosing, or prophylactically treating a disease, malignancy, or condition. |
| Use: Single domain antibody construct used for treating or diagnosing disease or malignancy (claimed), or viral infections.No biological data given. |
| Advantage: The single domain antibody construct provides enhanced efficacy in targeting brain tissue. |
| Novelty: Single domain antibody construct comprising first single domain antibody with binding domain, is new; where binding domain comprises first polypeptide comprising first complementarity determining regions encoding 25 sequences of 7 amino acids (SEQ ID NOs: 1-25), given in the specification; second complementarity determining regions encoding 25 sequences of 8 amino acids (SEQ ID NOs: 26-50), given in the specification; and third complementarity determining regions encoding 25 sequences of 9-15 amino acids (SEQ ID NOs: 51-75), given in the specification. |
| Filed: 10/12/2022 |
| Application Number: US17964213A |
| Tech ID: SD 15931.0 |
| This invention was made with Government support under Contract No. DE-NA0003525 awarded by the United States Department of Energy/National Nuclear Security Administration. The Government has certain rights in the invention. |
| Data from Derwent World Patents Index, provided by Clarivate All rights reserved. Republication or redistribution of Clarivate content, including by framing or similar means, is prohibited without the prior written consent of Clarivate. Clarivate and its logo, as well as all other trademarks used herein are trademarks of their respective owners and used under license. |