| Abstract: | A method and apparatus for measuring a biological attribute, such as the
concentration of an analyte, particularly a blood analyte in tissue such
as glucose. The method utilizes spectrographic techniques in conjunction
with an improved instrument-tailored or subject-tailored calibration
model. In a calibration phase, calibration model data is modified to
reduce or eliminate instrument-specific attributes, resulting in a
calibration data set modeling intra-instrument or intra-subject
variation. In a prediction phase, the prediction process is tailored for
each target instrument separately using a minimal number of spectral
measurements from each instrument or subject. |