Detection of electrophilic and nucleophilic chemical agents
| DWPI Title: New substituted 7-benzo(1,3)dioxol-5-yl-(1,3)dioxolo(4,5-g)isoquinoline compound useful as precursor sensor molecule for the detection of chemical agents e.g. chemical warfare agents |
| Abstract: A “real time” method for detecting chemical agents generally and particularly electrophilic and nucleophilic species by employing tunable, precursor sensor materials that mimic the physiological interaction of these agents to form highly florescent berberine-type alkaloids that can be easily and rapidly detected. These novel precursor sensor materials can be tuned for reaction with both electrophilic (chemical species, toxins) and nucleophilic (proteins and other biological molecules) species. By bonding or otherwise attaching these precursor molecules to a surface or substrate they can be used in numerous applications. |
| Use: As precursor sensor molecule (claimed) for the detection of chemical agents selected from electrophilic and nucleophilic species including chemical warfare agents (CWA) and biological warfare agents. |
| Advantage: The method detects chemical agents, preferably electrophilic and nucleophilic species by employing tunable, precursor sensor materials that mimic the physiological interaction of these agents to form highly florescent berberine-type alkaloids that can be easily and rapidly detected. The novel precursor sensor materials can be tuned for reaction with both electrophilic (chemical species, toxins) and nucleophilic (proteins and other biological molecules) species; can react with both electrophilic (chemical species, toxins) and nucleophilic species (amino acids, peptides, proteins and other biological molecules) to form highly fluorescent compounds and thus can be used to detect very low concentrations of chemical agents particularly hazardous chemical and biological materials and especially chemical and biological warfare agents. |
| Novelty: A substituted 7-benzo[1,3]dioxol-5-yl-[1,3]dioxolo[4,5-g]isoquinoline compound as precursor sensor molecule, is new. |
| Filed: 11/9/2007 |
| Application Number: US2007983500A |
| Tech ID: SD 8581.1 |
| This invention was made with Government support under Contract No. DE-NA0003525 awarded by the United States Department of Energy/National Nuclear Security Administration. The Government has certain rights in the invention. |
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