Method of multi-dimensional moment analysis for the characterization of signal peaks
| DWPI Title: Multi-dimensional moment analysis method for characterization of signal peaks to optimize operation of analytical system e.g. ion mobility spectrometer involves calculating moments in each dimension for each of two-dimensional signal peaks |
| Abstract: A method of multi-dimensional moment analysis for the characterization of signal peaks can be used to optimize the operation of an analytical system. With a two-dimensional Péclet analysis, the quality and signal fidelity of peaks in a two-dimensional experimental space can be analyzed and scored. This method is particularly useful in determining optimum operational parameters for an analytical system which requires the automated analysis of large numbers of analyte data peaks. For example, the method can be used to optimize analytical systems including an ion mobility spectrometer that uses a temperature stepped desorption technique for the detection of explosive mixtures. |
| Use: Multi-dimensional moment analysis method for characterization of signal peaks to optimize operation of analytical system such as ion mobility spectrometer (IMS). Can also be used with two-dimensional gel analysis in biological systems, hyphenated techniques such as gas chromatography coupled with mass spectrometry (GC-MS), time-frequency surface acoustic wave (SAW) tag data, geophysical analysis instruments for geophysical terrain mapping, navigation systems in mountainous areas, and effluent plume monitoring systems. |
| Advantage: Enables real-time separation of analytes in multicomponent mixture due to use of preconcentrator with temperature stepping. Provides additional dimension to differentiate between compounds when multiple component mixtures are present since separation in real-time domain is manipulated using temperature stepped desorption (TSD). Ensures optimization of the operational parameters of IMS system since peaks are automatically scored by employing two-dimensional Peclet method. |
| Novelty: The multi-dimensional moment analysis method involves calculating zero moment for each of signal peaks, calculating first moment in each dimension for each of signal peaks, and calculating second moment in each dimension for each of signal peaks. The operating parameter of analytical system e.g. ion mobility spectrometer (10) is selected based upon ratio of first and second moments of each signal peak. Each signal peak is two-dimensional signal peak with first dimension having drift time in ion mobility spectrometer and second dimension having real time desorption from preconcentrator (20). |
| Filed: 6/25/2009 |
| Application Number: US2009491733A |
| Tech ID: SD 11119.0 |
| This invention was made with Government support under Contract No. DE-NA0003525 awarded by the United States Department of Energy/National Nuclear Security Administration. The Government has certain rights in the invention. |
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