Materials and methods for stabilizing nanoparticles in salt solutions
| DWPI Title: New chemical compound of peptoid molecule with oligo(amino-substituted glycine) backbone molecule with predefined length and several chemical functionalities substituted on e.g. backbone molecule for concentrating protected nanoparticles |
| Abstract: Sequence-specific polymers are proving to be a powerful approach to assembly and manipulation of matter on the nanometer scale. Ligands that are peptoids, or sequence-specific N-functional glycine oligomers, allow precise and flexible control over the arrangement of binding groups, steric spacers, charge, and other functionality. We have synthesized short peptoids that can prevent the aggregation of gold nanoparticles in high-salt environments including divalent salt, and allow co-adsorption of a single DNA molecule. This degree of precision and versatility is likely to prove essential in bottom-up assembly of nanostructures and in biomedical applications of nanomaterials. |
| Use: For preparing several protected nanoparticles which is used for concentrating the protected nanoparticles and DNA-functionalized protected nanoparticles (claimed); for organizing nanoparticles in artificial structures which comprise materials having increased tolerance for biological environments such as blood or cytoplasm for use in medical or drug delivery applications, or for conditions in which biological macromolecules are used for assembly and fabrication of nanostructures. |
| Advantage: The peptoids stabilize 5-10 nm gold particles in solutions comprising high concentrations of monovalent salt, and moderate concentrations of divalent salt, and show that their interaction with thiolated DNA is similar to that of bis (p-sulfonato) triphenylphosphine (phosphine or phosphine ligand). This constitutes another strategy to facilitate DNA-nanoparticle interactions in nucleic acid nanostructures that may prove useful in biomedical applications of gold nanoparticles such as in gene delivery. |
| Novelty: A chemical compound comprising a peptoid molecule comprising an oligo(amino-substituted glycine) backbone molecule having a predefined length and several chemical functionalities substituted on the backbone molecule and/or terminal nitrogen atoms is new. The chemical functionalities are selected from and configured to stabilize a nanoparticle in a liquid solution comprising at least one salt having monovalent or divalent cation. |
| Filed: 1/12/2011 |
| Application Number: US13005250A |
| Tech ID: SD 11637.3 |
| This invention was made with Government support under Contract No. DE-NA0003525 awarded by the United States Department of Energy/National Nuclear Security Administration. The Government has certain rights in the invention. |
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