Biofouling-resistant ceragenin-modified materials and structures for water treatment
| DWPI Title: Biofouling-resistant material made by depositing UV-absorbing photoinitiator on polymer substrate surface, contacting with solution of e.g. alkene-functionalized ceragenin monomer and exposing to UV light, useful for treating waste water |
| Abstract: This invention relates to methods for chemically grafting and attaching ceragenin molecules to polymer substrates; methods for synthesizing ceragenin-containing copolymers; methods for making ceragenin-modified water treatment membranes and spacers; and methods of treating contaminated water using ceragenin-modified treatment membranes and spacers. Ceragenins are synthetically produced antimicrobial peptide mimics that display broad-spectrum bactericidal activity. Alkene-functionalized ceragenins (e.g., acrylamide-functionalized ceragenins) can be attached to polyamide reverse osmosis membranes using amine-linking, amide-linking, UV-grafting, or silane-coating methods. In addition, silane-functionalized ceragenins can be directly attached to polymer surfaces that have free hydroxyls. |
| Use: The biofouling-resistant material is useful as membrane or filter for waste water treatment and purification. |
| Advantage: The biofouling-resistant material: exhibits broad spectrum antibacterial activity for longer period of time; rapidly kills the microorganisms present in the waste water; and can be prepared in an economical manner. |
| Novelty: Biofouling-resistant material, made by a process of attaching alkene-functionalized ceragenins to a surface of polymer substrate using UV light, is claimed, where the process comprises: depositing UV-absorbing photoinitiator on a surface of the substrate; contacting substrate surface with monomer solution comprising alkene-functionalized ceragenin monomer, a comonomer and solvent; exposing monomer solution to UV light, to form radicals that initiate a polymerization reaction; and forming ceragenin-containing copolymer reaction products that are chemically grafted to substrate surface. |
| Filed: 1/7/2011 |
| Application Number: US2011986234A |
| Tech ID: SD 11236.3 |
| This invention was made with Government support under Contract No. DE-NA0003525 awarded by the United States Department of Energy/National Nuclear Security Administration. The Government has certain rights in the invention. |
| Data from Derwent World Patents Index, provided by Clarivate All rights reserved. Republication or redistribution of Clarivate content, including by framing or similar means, is prohibited without the prior written consent of Clarivate. Clarivate and its logo, as well as all other trademarks used herein are trademarks of their respective owners and used under license. |