Methods for attaching polymerizable ceragenins to water treatment membranes using amine and amide linkages
| DWPI Title: Attaching alkene-functionalized ceragenins to polymer substrate surface, used to treat contaminated water, comprises e.g. attaching alkenes to free amine groups of substrate and contacting formed functionalized surface with monomer solution |
| Abstract: This invention relates to methods for chemically grafting and attaching ceragenin molecules to polymer substrates; methods for synthesizing ceragenin-containing copolymers; methods for making ceragenin-modified water treatment membranes and spacers; and methods of treating contaminated water using ceragenin-modified treatment membranes and spacers. Ceragenins are synthetically produced antimicrobial peptide mimics that display broad-spectrum bactericidal activity. Alkene-functionalized ceragenins (e.g., acrylamide-functionalized ceragenins) can be attached to polyamide reverse osmosis membranes using amine-linking, amide-linking, UV-grafting, or silane-coating methods. In addition, silane-functionalized ceragenins can be directly attached to polymer surfaces that have free hydroxyls. |
| Use: The method is useful for attaching alkene-functionalized ceragenins to a surface of a polymer substrate (claimed) which is used treating contaminated water. No biological data given. |
| Advantage: The method: is cost-effective; and provides polymer substrate attached with alkene-functionalized ceragenins that can kill and sweep away the bacteria before they can colonize and form adherent biofilms, exhibits improved stability, flexibility and mobility, and has long life-time. |
| Novelty: Method (m1) of attaching alkene-functionalized ceragenins to a surface of a polymer substrate, comprises: providing the substrate with free amine groups on a surface of the substrate; attaching alkenes to the free amine groups, thus alkene-functionalizing the surface; contacting the alkene-functionalized surface with a monomer solution comprising an alkene-functionalized ceragenin monomer, a comonomer, an initiator, and a solvent, thus initiating a polymerization reaction; and forming ceragenin-containing copolymer reaction products that are chemically grafted to the surface of the substrate. |
| Filed: 1/7/2011 |
| Application Number: US2011986215A |
| Tech ID: SD 11236.1 |
| This invention was made with Government support under Contract No. DE-NA0003525 awarded by the United States Department of Energy/National Nuclear Security Administration. The Government has certain rights in the invention. |
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