Cell-based composite materials with programmed structures and functions
| DWPI Title: Producing cell silica composite (CSC) from biological material involves exposing biological material to suspension having dilute aqueous solution of silicic acid compound so producing CSC, where suspension does not form gel in exposing |
| Abstract: The present invention is directed to the use of silicic acid to transform biological materials, including cellular architecture into inorganic materials to provide biocomposites (nanomaterials) with stabilized structure and function. In the present invention, there has been discovered a means to stabilize the structure and function of biological materials, including cells, biomolecules, peptides, proteins (especially including enzymes), lipids, lipid vesicles, polysaccharides, cytoskeletal filaments, tissue and organs with silicic acid such that these materials may be used as biocomposites. In many instances, these materials retain their original biological activity and may be used in harsh conditions which would otherwise destroy the integrity of the biological material. In certain instances, these biomaterials may be storage stable for long periods of time and reconstituted after storage to return the biological material back to its original form. In addition, by exposing an entire cell to form CSCs, the CSCs may function to provide a unique system to study enzymes or a cascade of enzymes which are otherwise unavailable. |
| Use: Method for producing cell silica composite (CSC) from a biological material (claimed). |
| Advantage: The method enables to produce cell silica composite (CSC) from a biological material has silicic acid, which is used to transform biological materials, including cellular architecture into inorganic materials to provide biocomposites (nanomaterials) with stabilized structure and function including cells, biomolecules, peptides, proteins (especially enzymes), lipids, lipid vesicles, polysaccharides, cytoskeletal filaments, tissue and organs as these materials retain their original biological activity and are used in harsh conditions which otherwise destroys the integrity of the biological material. Biomaterials are storage stable for long periods of time and reconstituted after storage to return the biological material back to its original form and by exposing an entire cell to form CSCs, the CSCs function to provide a unique system to study enzymes or a cascade of enzymes. |
| Novelty: Producing cell silica composite (CSC) from a biological material involves exposing biological material to suspension having dilute aqueous solution of a silicic acid compound at a pH ranging from about 1.5-4.5 and a concentration from about 50-250 mM so producing CSC. Suspension does not form a gel in the exposing, where biological material is cell, tissue, organelle, organ or organism and silicic acid compound transforms biological material to provide CSC. |
| Filed: 4/24/2013 |
| Application Number: US13869799A |
| Tech ID: SD 12210.1 |
| This invention was made with Government support under Contract No. DE-NA0003525 awarded by the United States Department of Energy/National Nuclear Security Administration. The Government has certain rights in the invention. |
| Data from Derwent World Patents Index, provided by Clarivate All rights reserved. Republication or redistribution of Clarivate content, including by framing or similar means, is prohibited without the prior written consent of Clarivate. Clarivate and its logo, as well as all other trademarks used herein are trademarks of their respective owners and used under license. |