Fluid delivery manifolds and microfluidic systems
| DWPI Title: Fluid e.g. explosive residue, distribution manifold for microfluidic chip in cartridge of microfluidic system in laboratory, has fluid outlets in fluid communication with respective outlet locations |
| Abstract: Embodiments of fluid distribution manifolds, cartridges, and microfluidic systems are described herein. Fluid distribution manifolds may include an insert member and a manifold base and may define a substantially closed channel within the manifold when the insert member is press-fit into the base. Cartridges described herein may allow for simultaneous electrical and fluidic interconnection with an electrical multiplex board and may be held in place using magnetic attraction. |
| Use: Fluid distribution manifold for routing fluids such as biological fluid sample containing target analytes of interest e.g. protein, DNA, RNA, or explosive residue, buffer fluid and wash fluid, from one inlet location to multiple outlet locations in fluid communication with a microfluidic chip in a cartridge of a microfluidic system (all claimed) in a laboratory. |
| Advantage: The cartridge can allow for simultaneous electrical and fluidic interconnection with an electrical multiplex board, and can be held in place using magnetic attraction. The manifold provides for fluid routing, fluid interconnection, and/or electrical interconnection to a microfluidic chip. The fluidic and/or electrical connections can be used to perform microfluidic analysis techniques and carry fluids. The manifold uses a controller with processing units and in communication with a memory encoded with instructions causing a predetermined set of control signals to be generated to implement a particular microfluidic analysis within the microfluidic chip such that automated micofluidic analysis can be performed without requirement of a skilled technician for operation. The manifold reduces a number of fluid interconnects needed directly to the microfluidic chip from an external fluid source. The insert member can be formed from any machinable material including polymeric materials. The shape of the insert member is slightly larger than the shape of the indentation defined by the manifold base to facilitate press-fitting to form a fluid-tight seal. The manifold avoids or reduces bonding, adhesive, or other joining processes by press-fitting machined parts. The press-fitting can be performed manually or by machine. |
| Novelty: The manifold (805) has a channel for fluid communication between an inlet location and a set of outlet locations, and a manifold base (803) or an insert member (802) partially defining a fluid inlet from a first surface to a second surface of the manifold base and in fluid communication with the inlet location. One of the manifold base and the insert member partially defines a set of fluid outlets from the first surface to the second surface, where the fluid outlets are in fluid communication with the respective outlet locations. |
| Filed: 10/7/2010 |
| Application Number: US2010900276A |
| Tech ID: SD 11460.0 |
| This invention was made with Government support under Contract No. DE-NA0003525 awarded by the United States Department of Energy/National Nuclear Security Administration. The Government has certain rights in the invention. |
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