Check valves for microfluidic systems and methods thereof
| DWPI Title: Fluidic cartridge for west Nile virus (WNV) detection, has cavity that encompasses pre-stressed spring and elastomeric pad, and main microchannel that is provided in fluidic communication with valve seat |
| Abstract: The present invention relates to microfluidic check valves, as well as fluidic cartridges including such check valves. In particular examples, the check valve includes a pre-stressed spring formed from a planar substrate. Various characteristics of the valves, such as size, profile, opening pressure, etc., can be tuned to provide desired performance when employed within a fluidic cartridge. |
| Use: Fluidic cartridge for west Nile virus (WNV) detection. |
| Advantage: The improved designs of the cartridge allow for integrating the elegant and powerful check valves into point-of-care microfluidic diagnostics, in which robust sealing and passive fluid manipulation are useful. The silicone stiffness is increased to result in unacceptable opening pressure variability and poor leak performance under back pressure in laser-cut valves without an annular boss. The devices accurately and reliably detected WNV using endpoint detection, and prevented contamination of the lab space with amplicon. |
| Novelty: The cartridge (300) has an elastomeric pad that comprises a first surface and a second surface that opposes the first surface. The first surface is configured to releasably contact the inlet. A pre-stressed spring comprising multiple extended beams defined within a planar substrate and connected to a central support. The surface portion of the substrate is configured to contact a surface portion of the base. The central support is defined within the substrate and configured to align with the second surface of the elastomeric pad, and thus providing a pressurized seal between the inlet of the base, the elastomeric pad, and the central support of the spring. A lid comprises a cavity. The cavity is configured to encompass the pre-stressed spring and the elastomeric pad. A first valve seat (311) is configured to accommodate a first check valve (301). A main microchannel in fluidic communication is provided with the first valve seat. |
| Filed: 10/9/2019 |
| Application Number: US16597292A |
| Tech ID: SD 13724.2 |
| This invention was made with Government support under Contract No. DE-NA0003525 awarded by the United States Department of Energy/National Nuclear Security Administration. The Government has certain rights in the invention. |
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