Methods of producing lipid-derived compounds and host cells thereof
| DWPI Title: New isolated, genetically engineered host cell comprising first mutant gene that is deletion of a gene encoding cytoplasmic tRNA thiolation protein, and at least one expressed nucleic acids encoding fatty acyl-CoA reductase, or thioesterase, carboxylicacid reductase and aldehyde reductase |
| Abstract: The present disclosure relates to genetically engineered host cells and methods of producing a lipid-derived compound by employing such host cells. In particular embodiments, the host cell includes a first mutant gene encoding a cytoplasmic tRNA thiolation protein. Optionally, the host cell can include other mutant genes for decreasing fatty alcohol catabolism, decreasing re-importation of secreted fatty alcohol, or displaying other useful characteristics, as described herein. |
| Use: The cell is useful for: producing a lipid-derived compound by employing host cells. |
| Advantage: The cell provides high yield. |
| Novelty: Isolated, genetically engineered host cell comprising a first mutant gene that is a deletion of a gene encoding cytoplasmic tRNA thiolation protein, and at least one expressed nucleic acids encoding (1) fatty acyl-CoA reductase, or (2) thioesterase, carboxylicacid reductase and aldehyde reductase, is new. |
| Filed: 5/18/2021 |
| Application Number: US17323195A |
| Tech ID: SD 15568.0 |
| This invention was made with Government support under Contract No. DE-NA0003525 awarded by the United States Department of Energy/National Nuclear Security Administration. The Government has certain rights in the invention. |
| Data from Derwent World Patents Index, provided by Clarivate All rights reserved. Republication or redistribution of Clarivate content, including by framing or similar means, is prohibited without the prior written consent of Clarivate. Clarivate and its logo, as well as all other trademarks used herein are trademarks of their respective owners and used under license. |