Targeted near-infrared imaging by metal-organic frameworks

DWPI Title: Near-infrared imaging metal-organic framework used for near-infrared imaging of biological molecule, comprises metal cluster comprising rare earth metal ions, and carboxylic acid-based linkers coordinating with metal cluster, where carboxylic acid-based linkers further comprise amine groups
Abstract: Metal-organic frameworks (MOFs) comprising amines on the organic linker can be used for cell targeting. In particular, primary amine groups represent one of the most versatile chemical moieties for conjugation to biologically relevant molecules, including antibodies and enzymes. Different chemical conjugation schemes can be used to conjugate biological molecules to the amino functionality on the organic linker. For example, carbodiimide chemistry can be used to link a primary amine to available carboxyl groups on the protein. For example, sulfhydryl crosslinking chemistry can be used via Traut's reagent scheme. As a demonstration of the invention, the ability of EpCAM antibody-targeted MOFs to bind to a human epithelial cell line (A549), a common target for imaging studies, was confirmed with confocal microscopy.
Use: The near-infrared imaging metal-organic framework is used for near-infrared imaging of biological molecule (claimed) such as peptide, protein (including antibodies and enzymes), nucleic acid (including PNA and DNA), and polymer for magnetic resonance imaging (MRI), computed tomography (CT), positron emission tomography (PET), intracellular biosensing and optical imaging.
Advantage: The near-infrared imaging metal-organic framework increases quantum yield, and allows more specificity in attaching the biological molecule to the metal-organic framework.
Novelty: Near-infrared imaging metal-organic framework comprises metal cluster comprising rare earth metal ions, and carboxylic acid-based linkers coordinating with the at one metal cluster, where the carboxylic acid-based linkers further comprise amine groups within the linker.
Filed: 4/28/2021
Application Number: US17243417A
Tech ID: SD 15387.0
This invention was made with Government support under Contract No. DE-NA0003525 awarded by the United States Department of Energy/National Nuclear Security Administration. The Government has certain rights in the invention.
Data from Derwent World Patents Index, provided by Clarivate
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