Electrophoretic device and method to separate and detect analyte ions

DWPI Title: Method for separating and detecting analyte of ionic and isotopic species using capillary zone electrophoresis, involves providing electrophoretic device and providing array of aligned hollow channels in porous substrate
Abstract: This invention is directed to an inexpensive, miniaturized, portable, low-power device and method for electrophoretic separation and electrochemical detection of an analyte, including different isotopes of the same element. The invention replaces a conventional or microfabricated capillary electrophoresis tube with a microchip comprising an array of parallel electrophoretic separation nanotubes or aligned hollow channels fabricated in a porous substrate.
Use: Method for separating and detecting an analyte of ionic and isotopic species using capillary zone electrophoresis.
Advantage: Entrance to the channel can provide more efficient injection of the ionized analyte into the hollow channels. More uniform electrophoretic electric field can be provided in the hollow channels.
Novelty: The method involves providing an electrophoretic device. An array of aligned hollow channels is provided in a porous substrate. An electrophoresis electric field is applied between the entrance and the exit of the array of aligned hollow channels (100). The analyte source (102) is preconcentrated on the injection electrode (101). A pulse of two ionized species is injected into the array of aligned hollow channels. The two ionized species are electrophoretically separated in the electrophoresis electric field applied to the array of aligned hollow channels. The analyte includes isotopes of a chemical species and a metal.
Filed: 10/9/2020
Application Number: US17066703A
Tech ID: SD 14227.3
This invention was made with Government support under Contract No. DE-NA0003525 awarded by the United States Department of Energy/National Nuclear Security Administration. The Government has certain rights in the invention.
Data from Derwent World Patents Index, provided by Clarivate
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