Methods and systems for opioid detection

DWPI Title: Detecting opioid compound involves capturing opioid compound on metal mesh comprising surface area, thermally decomposing captured material on metal mesh, thermally decomposing obtained backbone fragments, capturing and separating backbone fragments and secondary fragments, and eluting
Abstract: The present invention relates to detection systems for detecting an opioid compound by use of pyrolysis, as well as methods thereof. In particular, the systems are configured to detect the presence of a backbone fragment indicative of a class of opioid compounds, including opioid analogues.
Use: Method of detecting opioid compound.
Advantage: The method enables detection of opioid compound which is independent of drug's chemical structure, and reports the presence of synthetic opioid.
Novelty: Detecting opioid compound involves: (i) capturing opioid compound on metal mesh comprising surface area, where the metal mesh is provided in a front-end; (ii) thermally decomposing the captured material on metal mesh at an elevated temperature of 500-900°C to obtain backbone fragments indicative of a compound in an opioid class; (iii) thermally decomposing backbone fragments at a further elevated temperature to obtain secondary fragments; (iv) capturing and separating backbone fragments and secondary fragments in a micro gas chromatograph (213) comprising column and stationary phase disposed on surface of the column, where the stationary phase is configured to interact with backbone fragments and secondary fragments; and (v) eluting backbone fragments and secondary fragments from the micro gas chromatograph column to micro detector (214), where the micro detector is configured to detect the presence of backbone fragments and secondary fragments.
Filed: 8/4/2020
Application Number: US16984923A
Tech ID: SD 14769.1
This invention was made with Government support under Contract No. DE-NA0003525 awarded by the United States Department of Energy/National Nuclear Security Administration. The Government has certain rights in the invention.
Data from Derwent World Patents Index, provided by Clarivate
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