Surface engineered nanoparticles for improved surface enhanced Raman scattering applications and method for preparing same
| DWPI Title: Preparation of surface enhanced Raman spectroscopy gold nanoparticles used as signal-enhancing substrate for analyte detection, comprises reacting reducing agent and gold salt solution in emulsion mixture, and separating precipitate |
| Abstract: A method for producing metal nanoparticles that when associated with an analyte material will generate an amplified SERS spectrum when the analyte material is illuminated by a light source and a spectrum is recorded. The method for preparing the metal nanoparticles comprises the steps of (i) forming a water-in-oil microemulsion comprising a bulk oil phase, a dilute water phase, and one or more surfactants, wherein the water phase comprises a transition metal ion; (ii) adding an aqueous solution comprising a mild reducing agent to the water-in-oil microemulsion; (iii) stirring the water-in-oil microemulsion and aqueous solution to initiate a reduction reaction resulting in the formation of a fine precipitate dispersed in the water-in-oil microemulsion; and (iv) separating the precipitate from the water-in-oil microemulsion. |
| Use: Preparation of surface enhanced Raman spectroscopy gold nanoparticles used as signal-enhancing substrate for analyte detection using Raman spectroscopy. |
| Advantage: The gold nanoparticles have unique truncated morphology broadly characterized as stellated icosahedra and unique spectroscopic characteristics; and can be synthesized at temperatures at or near room temperature. |
| Novelty: Preparation of surface enhanced Raman spectroscopy (SERS) gold nanoparticles comprises forming first emulsion; forming second emulsion; adding second emulsion to first emulsion to provide emulsion mixture; stirring emulsion mixture to initiate reduction reaction between reducing agent and gold salt solution to provide precipitate dispersed in emulsion mixture; and separating precipitate from emulsion mixture to provide gold nanoparticles having nanoscale roughened surface structure. |
| Filed: 9/16/2005 |
| Application Number: US2005228934A |
| Tech ID: SD 8588.0 |
| This invention was made with Government support under Contract No. DE-NA0003525 awarded by the United States Department of Energy/National Nuclear Security Administration. The Government has certain rights in the invention. |
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