Selective oxidation of 5-methylcytosine by TET-family proteins
| Patent Number: | 10,731,204 |
| Issued: | 8/4/2020 |
| Official Filing: | View the Complete Patent |
| Abstract: | The present invention provides for novel methods for regulating and detecting the cytosine methylation status of DNA. The invention is based upon identification of a novel and surprising catalytic activity for the family of TET proteins, namely TET1, TET2, TET3, and CXXC4. The novel activity is related to the enzymes being capable of converting the cytosine nucleotide 5-methylcytosine into 5-hydroxymethylcytosine by hydroxylation. |
| Filed: | 10/5/2017 |
| Application Number: | 15/725,917 |
| Government Interests: | STATEMENT OF GOVERNMENT INTEREST This invention was made with Government support under Contract No. DE-NA0003525 awarded by the United States Department of Energy/National Nuclear Security Administration. The Government has certain rights in the invention. |