| Abstract: The present invention provides for novel methods for regulating and
detecting the cytosine methylation status of DNA. The invention is based
upon identification of a novel and surprising catalytic activity for the
family of TET proteins, namely TET1, TET2, TET3, and CXXC4. The novel
activity is related to the enzymes being capable of converting the
cytosine nucleotide 5-methylcytosine into 5-hydroxymethylcytosine by
hydroxylation. |
| Filed: 10/5/2017 |
| Application Number: 15/725917 |
| This invention was made with Government support under Contract No. DE-NA0003525 awarded by the United States Department of Energy/National Nuclear Security Administration. The Government has certain rights in the invention. |
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