| Abstract: A microfluidic acoustic-based cell lysing device that can be integrated
with on-chip nucleic acid extraction. Using a bulk acoustic wave (BAW)
transducer array, acoustic waves can be coupled into microfluidic
cartridges resulting in the lysis of cells contained therein by localized
acoustic pressure. Cellular materials can then be extracted from the
lysed cells. For example, nucleic acids can be extracted from the lysate
using silica-based sol-gel filled microchannels, nucleic acid binding
magnetic beads, or Nafion-coated electrodes. Integration of cell lysis
and nucleic acid extraction on-chip enables a small, portable system that
allows for rapid analysis in the field. |
| Filed: 8/31/2010 |
| Application Number: 12/872919 |
| This invention was made with Government support under Contract No. DE-NA0003525 awarded by the United States Department of Energy/National Nuclear Security Administration. The Government has certain rights in the invention. |
| Attribution for Derwent World Patents Index Records published on Sandia ® Clarivate. All rights reserved. Republication or redistribution of Clarivate content, including by framing or similar means, is prohibited without the prior written consent of Clarivate. Clarivate and its logo, as well as all other trademarks used herein are trademarks of their respective owners and used under license. |