| Abstract: Embodiments of the present invention are directed toward devices,
systems, and method for conducting nucleic acid purification and
quantification using sedimentation. In one example, a method includes
generating complexes which bind to a plurality of beads in a fluid
sample, individual ones of the complexes comprising a nucleic acid
molecule such as DNA or RNA and a labeling agent. The plurality of beads
including the complexes may be transported through a density media,
wherein the density media has a density lower than a density of the beads
and higher than a density of the fluid sample, and wherein the
transporting occurs, at least in part, by sedimentation. Signal may be
detected from the labeling agents of the complexes. |
| Filed: 3/16/2012 |
| Application Number: 13/423008 |
| This invention was made with Government support under Contract No. DE-NA0003525 awarded by the United States Department of Energy/National Nuclear Security Administration. The Government has certain rights in the invention. |
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