Microfluidic hubs, systems, and methods for interface fluidic modules

United States Patent

January 27, 2015
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Automated Molecular Biology Platform
Microfluidic Devices
Embodiments of microfluidic hubs and systems are described that may be used to connect fluidic modules. A space between surfaces may be set by fixtures described herein. In some examples a fixture may set substrate-to-substrate spacing based on a distance between registration surfaces on which the respective substrates rest. Fluidic interfaces are described, including examples where fluid conduits (e.g. capillaries) extend into the fixture to the space between surfaces. Droplets of fluid may be introduced to and/or removed from microfluidic hubs described herein, and fluid actuators may be used to move droplets within the space between surfaces. Continuous flow modules may be integrated with the hubs in some examples.
April 25, 2012
204/601; 422/502; 422/504;
G01N 27/447 (20060101);
;204/451,601 ;422/502,504
STATEMENT REGARDING RESEARCH & DEVELOPMENT The United States Government has a paid-up license in this invention and the right in limited circumstances to require the patent owner to license others on reasonable terms as provided for by the terms of contract No. DE-AC04-94AL85000 awarded by the U.S. Department of Energy to Sandia Corporation.