| Abstract: | Methods, structures, and systems are disclosed for biosensing and drug
delivery techniques. In one aspect, a^ device for detecting an analyte
and/or releasing a biochemical into a biological fluid can include an
array of hollowed needles, in which each needle includes a protruded
needle structure including an exterior wall forming a hollow interior and
an opening at a terminal end of the protruded needle structure that
exposes the hollow interior, and a probe inside the exterior wall to
interact with one or more chemical or biological substances that come in
contact with the probe via the opening to produce a probe sensing signal,
and an array of wires that are coupled to probes of the array of hollowed
needles, respectively, each wire being electrically conductive to
transmit the probe sensing signal produced by a respective probe. |