| Abstract: | The present invention, in part, relates to an apparatus having a
single-use, normally-closed fluidic valve that is initially maintained in
the closed position by a valve element bonded to an adhesive coating. The
valve is opened using a magnetic force. The valve element includes a
magnetic material or metal. In some examples, the valve is opened by
bringing a magnet in proximity to the valve element to provide a magnetic
force that delaminates the valve element from the adhesive coating. In
particular, the apparatus can be useful for on-chip amplification and/or
detection of various targets, including biological targets and any
amplifiable targets. Such apparatuses and methods are useful for in-field
or real-time detection of targets, especially in limited resource
settings. |