Microfluidic Devices

Technology Summary

Sandia National Laboratories has been working on the forefront of microfluidics device and component development for over twenty years and has amassed a sizable patent portfolio, a portion of which is now available for licensing as a bundle of 50+ patents for one simple fee. To further Sandia’s goal of disseminating and transferring taxpayer-funded technology into the private sector, this bundle is offered for non-exclusive licensing with an up-front fee of $25,000 and nominal periodic maintenance fees.

Description

The inventions, devices, and methods comprising this intellectual property bundle were primarily developed in support of Sandia’s national security mission in chemical and biological defense, and as such, reflect an emphasis on compact, portable form factors and the low power and high reliability needed for extended field deployment. These bundled patents largely fall under three broad categories: chip-based devices and diagnostics, microfluidic interconnects and interfaces, and materials and fabrication methods. Licensed together, the contents of the bundle represent a broad-based suite of building blocks offering particular benefit to applications including laboratory automation, chemical and biological sample preparation and purification, separation science, analytical chemistry instrumentation, material synthesis, system integration, and biomedical diagnostics. Bundled patents include a number of capillary microfluidic valves and fittings, a unique digital microfluidic interface, methods for producing axisymmetric coaxial flow fields in a chip-based format. Also featured are interconnect devices which offer several components that can act as manifolds, check valves, or ultra-high pressure pumps. These can be used to construct devices that change the flow rate of the material and sample to detection units–including laser induced fluorescence, mass spectroscopy detectors, and flow cytometry. The fabrication materials and technologies allow the connections between microfluidic devices and external components while increasing the number of functional components that can be connected to a microfluidic device. Sandia National Laboratories does not sell its products and relies on licenses like this to commercialize its technology into unique devices that reflect an emphasis on portability and reliability.

Benefits

  • Sample concentration & efficient delivery to chip
  • Mass manufacturing methods
  • Multiple fluidic connections
  • Increased number of external components

Applications and Industries

  • Bioscience R&D
  • Medical Point-of-Care
  • Remote Sampling
  • Pharmaceuticals
  • Veterinary

Intellectual Property

Title
ID Number
Patent Number
Date
Coaxial microreactor for particle synthesis 8,563,325 10/22/2013
Issued
Fabrication of small-scale structures with non-planar features 9,190,736 11/17/2015
Issued
Microfluidic devices and methods for integrated flow cytometry 11030.1 7,999,937 08/16/2011
Issued
Microfluidic structures and methods for integrating a functional component into a microfluidic device 8419.0 7,351,380 04/01/2008
Issued
Low power, scalable multichannel high voltage controller 8409.1 7,348,688 03/25/2008
Issued
Electrodes for microfluidic applications 8420.0 7,094,326 08/22/2006
Issued
Methods, microfluidic devices, and systems for detection of an active enzymatic agent 8,871,496 10/28/2014
Issued
Micromanifold assembly 8367.0 7,553,455 06/30/2009
Issued
Apparatus and method for selectively channeling a fluid 7704.0 7,314,208 01/01/2008
Issued
Electrokinetic concentration of charged molecules 8199.0 6,428,666 08/06/2002
Issued
Packaging of electro-microfluidic devices 6729.0 6,443,179 09/03/2002
Issued
Formation of interconnections to microfluidic devices 6817.0 6,599,436 07/29/2003
Issued
Modular high voltage power supply for chemical analysis 8427.2 7,710,086 05/04/2010
Issued
Modular high voltage power supply for chemical analysis 8427.1 7,400,119 07/15/2008
Issued
Modular high voltage power supply for chemical analysis 8427.0 7,161,334 01/09/2007
Issued
Method for eliminating gas blocking in electrokinetic pumping systems 8208.0 6,287,440 09/11/2001
Issued
Bonding thermoplastic polymers 8591.0 7,390,377 06/24/2008
Issued
Method for a microfluidic weaklink device 8474.1 7,625,474 12/01/2009
Issued
High-pressure microhydraulic actuator 8498.0 7,384,526 06/10/2008
Issued
Mobile monolithic polymer elements for flow control in microfluidic devices 8386.0 6,952,962 10/11/2005
Issued
Edge compression manifold apparatus 8366.1 7,182,371 02/27/2007
Issued
Electrokinetic high pressure hydraulic system 8112.2 6,277,257 08/21/2001
Issued
MEMS fluidic actuator 7544.0 7,246,524 07/24/2007
Issued
Method for producing a thin sample band in a microchannel device 8263.0 6,770,182 08/03/2004
Issued
Portable apparatus for separating sample and detecting target analytes 8412.1 7,452,507 11/18/2008
Issued
Electrokinetic high pressure hydraulic system 8112.1 6,019,882 02/01/2000
Issued
Method for making electro-fluidic connections in microfluidic devices 6547.0 6,772,513 08/10/2004
Issued
Surface-micromachined microfluidic devices 6694.1 6,797,187 09/28/2004
Issued
Microfluidic devices and methods including porous polymer monoliths 8,703,058 04/22/2014
Issued
Mobile monolithic polymer elements for flow control in microfluidic devices 8386.1 6,988,402 01/24/2006
Issued
Mobile monolithic polymer elements for flow control in microfluidic devices 8298.0 6,782,746 08/31/2004
Issued
Method and apparatus for controlling cross contamination of microfluid channels 8289.0 6,994,826 02/07/2006
Issued
Micro-fluidic interconnect 7047.0 7,004,198 02/28/2006
Issued
Surface-micromachined microfluidic devices 6694.0 6,537,437 03/25/2003
Issued
Method for forming polymerized microfluidic devices 8,047,829 11/01/2011
Issued
Low power, scalable multichannel high voltage controller 8409.0 7,012,342 03/14/2006
Issued
Packaging of electro-microfluidic devices 6816.0 6,548,895 04/15/2003
Issued
Micropores and methods of making and using thereof 9,404,913 08/02/2016
Issued
Devices, systems, and methods for microscale isoelectric fractionation 9,409,357 08/09/2016
Issued
Method for producing high dielectric strength microvalves 8421.1 7,022,381 04/04/2006
Issued
Protein detection system 8496.1 7,527,977 05/05/2009
Issued
Methods for integrating a functional component into a microfluidic device 8,808,588 08/19/2014
Issued
Apparatus and method for concentrating and filtering particles suspended in a fluid 8483.1 7,534,334 05/19/2009
Issued
Method of packaging and assembling micro-fluidic device 6816.1 6,821,819 11/23/2004
Issued
Castable three-dimensional stationary phase for electric field-driven applications 8335.1 7,488,407 02/10/2009
Issued
Method for forming polymerized microfluidic devices 8,394,312 03/12/2013
Issued
Method of using sacrificial materials for fabricating internal cavities in laminated dielectric structures 7292.0 7,494,557 02/24/2009
Issued
Castable three-dimensional stationary phase for electric field-driven applications 8335.0 6,846,399 01/25/2005
Issued
Passive injection control for microfluidic systems 8291.0 6,833,068 12/21/2004
Issued
Microfluidic channel fabrication method 8237.0 6,210,986 04/03/2001
Issued
Microfluidic hubs, systems, and methods for interface fluidic modules 8,940,147 01/27/2015
Issued
Micromanifold assembly 8,163,254 04/24/2012
Issued
Method and apparatus for reducing sample dispersion in turns and junctions of microchannel systems 8209.2 6,733,730 05/11/2004
Issued
Development StagePrototypeAvailabilityAvailablePublished11/03/2016Last Updated06/07/2017