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Shape-preserving polymeric replication of biological matter

United States Patent

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March 16, 2021
View the Complete Patent at the US Patent & Trademark Office
Shape-Preserving Polymeric Replication of Biological Materials
The present invention relates to a method of forming silica nanolayers on or within a biological sample, thereby capturing structural details that are present in the sample. The resultant silica composite or silica replica, in turn, can be employed as a template for a replica having those structural details captured in a polymer. Also provided herein are synthetic constructs including a polymeric replica, which can have any useful feature (e.g., oxygen-binding capacity).
16/ 711,150
December 11, 2019
C08G 83/00 (20060101)A61K 49/00 (20060101)A61K 31/80 (20060101)
STATEMENT OF GOVERNMENT INTEREST This invention was made with Government support under contract no. DE-AC04-94AL85000 awarded by the U.S. Department of Energy to Sandia Corporation. The Government has certain rights in the invention.