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Detection of active and latent infections with microfluidic devices and systems thereof

United States Patent

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September 29, 2020
View the Complete Patent at the US Patent & Trademark Office
The present invention relates to methods of detecting one or more targets of interest in a sample. In one instance, the target can be correlated to an active infection (e.g., by a virus and/or a bacterium). Methods can include treating the sample with a dissociation agent, thereby releasing the target of interest for more accurate detection (e.g., by use of a sedimentation-based centrifugal microfluidic devices). Also described herein are microfluidic devices and systems for use with a dissociation agent.
15/ 785,708
October 17, 2017
G01N 33/00 (20060101)G01N 33/53 (20060101)B01L 3/00 (20060101)B01J 4/02 (20060101)G01N 35/08 (20060101)G01N 35/00 (20060101)
STATEMENT OF GOVERNMENT INTEREST This invention was made with Government support under Contract No. DE-NA0003525 awarded by the United States Department of Energy/National Nuclear Security Administration. The Government has certain rights in the invention.