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Selective oxidation of 5-methylcytosine by TET-family proteins

United States Patent

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10,731,204
August 4, 2020
View the Complete Patent at the US Patent & Trademark Office
The present invention provides for novel methods for regulating and detecting the cytosine methylation status of DNA. The invention is based upon identification of a novel and surprising catalytic activity for the family of TET proteins, namely TET1, TET2, TET3, and CXXC4. The novel activity is related to the enzymes being capable of converting the cytosine nucleotide 5-methylcytosine into 5-hydroxymethylcytosine by hydroxylation.
15/725,917
October 5, 2017
1/1;
C12Q 1/6827 (20180101); C12Q 1/6869 (20180101); C12Q 1/6806 (20180101); G01N 33/53 (20060101); C12Q 1/26 (20060101);
GOVERNMENT SUPPORT This invention was made with government support under grant numbers AI044432 HL089150 awarded by The National Institutes of Health. The government has certain rights in the invention.