Miniature acoustic wave lysis system and uses thereof

United States Patent

December 6, 2016
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Miniature Acoustic Wave Lysis System (mALS)
The present invention relates to an acoustic lysis system including a disposable cartridge that can be reversibly coupled to a platform having a small, high-frequency piezoelectric transducer array. In particular, the system releases viable DNA, RNA, and proteins from human or bacterial cells, without chemicals or additional processing, to enable high-speed sample preparation for clinical point-of-care medical diagnostics and use with nano/microfluidic cartridges. Also described herein are methods of making and using the system of the invention.
June 27, 2014
C12N 13/00 (20060101); C12M 1/33 (20060101); G01N 29/036 (20060101); G01N 29/02 (20060101); H03H 9/145 (20060101); H03H 9/02 (20060101);
STATEMENT OF GOVERNMENT INTEREST This invention was made with Government support under contract no. DE-AC04-94AL85000 awarded by the U.S. Department of Energy to Sandia Corporation. The Government has certain rights in the invention.