Devices, systems, and methods for conducting sandwich assays using sedimentation

Patent Number: 8,945,914
Issued: 2/3/2015
Official Filing: View the Complete Patent
Abstract: Embodiments of the present invention are directed toward devices, systems, and method for conducting sandwich assays using sedimentation. In one example, a method includes generating complexes on a plurality of beads in a fluid sample, individual ones of the complexes comprising a capture agent, a target analyte, and a labeling agent. The plurality of beads including the complexes may be transported through a density media, wherein the density media has a density lower than a density of the beads and higher than a density of the fluid sample, and wherein the transporting occurs, at least in part, by sedimentation. Signal may be detected from the labeling agents of the complexes.
Filed: 9/28/2010
Application Number: 12/891,977
Related Opportunity: ViralFx
SpinDx™: Point-of-Care Diagnostics Using Centrifugal Microfluidics
Government Interests: STATEMENT OF GOVERNMENT INTEREST This invention was made with Government support under Contract No. DE-NA0003525 awarded by the United States Department of Energy/National Nuclear Security Administration. The Government has certain rights in the invention.