Dielectrokinetic chromatography devices

United States Patent

8,911,606
December 16, 2014
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Disclosed herein are methods and devices for dielectrokinetic chromatography. As disclosed, the devices comprise microchannels having at least one perturber which produces a non-uniformity in a field spanning the width of the microchannel. The interaction of the field non-uniformity with a perturber produces a secondary flow which competes with a primary flow. By decreasing the size of the perturber the secondary flow becomes significant for particles/analytes in the nanometer-size range. Depending on the nature of a particle/analyte present in the fluid and its interaction with the primary flow and the secondary flow, the analyte may be retained or redirected. The composition of the primary flow can be varied to affect the magnitude of primary and/or secondary flows on the particles/analytes and thereby separate and concentrate it from other particles/analytes.
14/050,502
October 10, 2013
204/643; 204/547; 210/198.2; 210/321.6; 210/656; 422/68.1; 422/82.01; 435/287.1; 73/863.23;
G01N 27/447 (20060101); G01N 27/26 (20060101); B01D 15/08 (20060101); B01D 63/00 (20060101);
;204/547,643,600 ;210/321.6,196.2,656 ;422/68.1,82.01 ;435/287.1
STATEMENT OF GOVERNMENT INTEREST The United States Government has rights in this invention pursuant to Contract No. DE-AC04-94AL85000 between the United States Department of Energy and Sandia Corporation, for the operation of the Sandia National Laboratories.