Preconcentration and separation of analytes in microchannels
United States Patent
| 7,828,948 | |
| November 9, 2010 | |
| View the Complete Patent at the US Patent & Trademark Office | |
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Microscale Immune and Cell Analysis (MICA) Rapid Automated Point-of-Care System (RapiDx) |
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| Disclosed herein are methods and devices for preconcentrating and separating analytes such as proteins and polynucleotides in microchannels. As disclosed, at least one size-exclusion polymeric element is adjacent to processing area or an assay area in a microchannel which may be porous polymeric element. The size-exclusion polymeric element may be used to manipulate, e.g. concentrate, analytes in a sample prior to assaying in the assay area. | |
| Hatch; Anson (Tracy, CA), Singh; Anup K. (Danville, CA), Herr; Amy E. (Fremont, CA), Throckmorton; Daniel J. (Tracy, CA) | |
| Sandia Corporation (Livermore, CA) | |
| 11/536,753 | |
| September 29, 2006 | |
| 204/455 ; 204/605; | |
| B01D 57/02 (20060101); B01D 61/58 (20060101); B01D 63/00 (20060101); | |
| 204/451,455,601,605 | |
| ACKNOWLEDGEMENT OF GOVERNMENT SUPPORT This invention was made with Government support under government contract DE-AC04-94AL85000 awarded by the U.S. Department of Energy to Sandia Corporation. The Government has certain rights in the invention. |