Preconcentration and separation of analytes in microchannels

Patent Number:	7,828,948
Issued:	November 9, 2010
Official Filing:	View the Complete Patent at the US Patent & Trademark Office
Technology:	Microscale Immune and Cell Analysis (MICA) Rapid Automated Point-of-Care System (RapiDx)
Abstract:	Disclosed herein are methods and devices for preconcentrating and separating analytes such as proteins and polynucleotides in microchannels. As disclosed, at least one size-exclusion polymeric element is adjacent to processing area or an assay area in a microchannel which may be porous polymeric element. The size-exclusion polymeric element may be used to manipulate, e.g. concentrate, analytes in a sample prior to assaying in the assay area.
Inventors:	Hatch; Anson (Tracy, CA), Singh; Anup K. (Danville, CA), Herr; Amy E. (Fremont, CA), Throckmorton; Daniel J. (Tracy, CA)
Assignee:	Sandia Corporation (Livermore, CA)
Application Number:	11/536,753
Filed:	September 29, 2006
Current U.S. Class:	204/455 ; 204/605;
Current International Class:	B01D 57/02 (20060101); B01D 61/58 (20060101); B01D 63/00 (20060101);
Field of Search:	204/451,455,601,605
Government Interests:	ACKNOWLEDGEMENT OF GOVERNMENT SUPPORT This invention was made with Government support under government contract DE-AC04-94AL85000 awarded by the U.S. Department of Energy to Sandia Corporation. The Government has certain rights in the invention.