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Preconcentration and separation of analytes in microchannels

United States Patent

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7,828,948
November 9, 2010
View the Complete Patent at the US Patent & Trademark Office
Microscale Immune and Cell Analysis (MICA)
Rapid Automated Point-of-Care System (RapiDx)
Disclosed herein are methods and devices for preconcentrating and separating analytes such as proteins and polynucleotides in microchannels. As disclosed, at least one size-exclusion polymeric element is adjacent to processing area or an assay area in a microchannel which may be porous polymeric element. The size-exclusion polymeric element may be used to manipulate, e.g. concentrate, analytes in a sample prior to assaying in the assay area.
Hatch; Anson (Tracy, CA), Singh; Anup K. (Danville, CA), Herr; Amy E. (Fremont, CA), Throckmorton; Daniel J. (Tracy, CA)
Sandia Corporation (Livermore, CA)
11/536,753
September 29, 2006
204/455 ; 204/605;
B01D 57/02 (20060101); B01D 61/58 (20060101); B01D 63/00 (20060101);
204/451,455,601,605
ACKNOWLEDGEMENT OF GOVERNMENT SUPPORT This invention was made with Government support under government contract DE-AC04-94AL85000 awarded by the U.S. Department of Energy to Sandia Corporation. The Government has certain rights in the invention.