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Protein detection system

United States Patent

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7,527,977
May 5, 2009
View the Complete Patent at the US Patent & Trademark Office
Microfluidic Devices
The present embodiment describes a miniature, microfluidic, absorption-based sensor to detect proteins at sensitivities comparable to LIF but without the need for tagging. This instrument utilizes fiber-based evanescent-field cavity-ringdown spectroscopy, in combination with faceted prism microchannels. The combination of these techniques will increase the effective absorption path length by a factor of 10.sup.3 to 10.sup.4 (to .about.1-m), thereby providing unprecedented sensitivity using direct absorption. The coupling of high-sensitivity absorption with high-performance microfluidic separation will enable real-time sensing of biological agents in aqueous samples (including aerosol collector fluids) and will provide a general method with spectral fingerprint capability for detecting specific bio-agents.
Fruetel; Julie A. (Livermore, CA)Fiechtner; Gregory J. (Bethesda, MD)Kliner; Dahv A. V. (San Ramon, CA)McIlroy; Andrew (Livermore, CA)
Sandia Corporation (Livermore, CA)
11/ 087,942
March 22, 2005
436/180 422/417422/504422/82.11
B01L 3/02 (20060101)
422/99,100,102,81,82.11436/180,174
STATEMENT OF GOVERNMENT INTEREST This invention was made with Government support under government contract no. DE-AC04-94AL85000 awarded by the U.S. Department of Energy to Sandia Corporation. The Government has certain rights in the invention, including a paid-up license and the right, in limited circumstances, to require the owner of any patent issuing in this invention to license others on reasonable terms.