Licensing Opportunity Contact Form
Submission of this form should not be interpreted as an offer to license technology. All licenses are subject to negotiation and availablility of the intellectual property for licensing. This form is intended for indications of interest only.

Search/Browse Tech

Protein detection system

United States Patent

To discuss licensing opportunities, fill out our Contact Form 
May 5, 2009
View the Complete Patent at the US Patent & Trademark Office
Microfluidic Devices
The present embodiment describes a miniature, microfluidic, absorption-based sensor to detect proteins at sensitivities comparable to LIF but without the need for tagging. This instrument utilizes fiber-based evanescent-field cavity-ringdown spectroscopy, in combination with faceted prism microchannels. The combination of these techniques will increase the effective absorption path length by a factor of 10.sup.3 to 10.sup.4 (to .about.1-m), thereby providing unprecedented sensitivity using direct absorption. The coupling of high-sensitivity absorption with high-performance microfluidic separation will enable real-time sensing of biological agents in aqueous samples (including aerosol collector fluids) and will provide a general method with spectral fingerprint capability for detecting specific bio-agents.
Fruetel; Julie A. (Livermore, CA)Fiechtner; Gregory J. (Bethesda, MD)Kliner; Dahv A. V. (San Ramon, CA)McIlroy; Andrew (Livermore, CA)
Sandia Corporation (Livermore, CA)
11/ 087,942
March 22, 2005
436/180 422/417422/504422/82.11
B01L 3/02 (20060101)
STATEMENT OF GOVERNMENT INTEREST This invention was made with Government support under government contract no. DE-AC04-94AL85000 awarded by the U.S. Department of Energy to Sandia Corporation. The Government has certain rights in the invention, including a paid-up license and the right, in limited circumstances, to require the owner of any patent issuing in this invention to license others on reasonable terms.